R. Ghai

Structural basis for inhibition of βFXIIa by garadacimab

This paper presents a high-resolution cryo-EM structure of garadacimab Fab bound to βFXIIa, revealing its unique binding mechanism and insights into FXII inhibition in HAE.

Phenology and ecological role of Aerobic Anoxygenic Phototrophs in fresh waters

This study investigates the seasonal dynamics of aerobic anoxygenic phototrophic bacteria in a freshwater lake, revealing their role in organic matter recycling and ecological dynamics.

Cross-sector collaboration reduces SARS-CoV-2 risk in deer

The paper models SARS-CoV-2 transmission dynamics in white-tailed deer across sectors and finds that cross-sector collaboration is most effective in reducing risk.

Rickettsiales' deep evolutionary history sheds light on the emergence of intracellular lifestyles

This study investigates the evolutionary history of Rickettsiales bacteria, showing how cross-feeding interactions with eukaryotes influenced their transition to intracellular lifestyles and genomic adaptations.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

The paper identifies the structural basis of the interaction between SNX17 and PDLIM family proteins, revealing a specific PDZ binding motif and unique electrostatic contacts.

Quorum sensing signals from epibiont mediate the induction of bioactive peptides in mat-forming cyanobacteria Nostoc

This study identifies quorum sensing signals from epibionts that induce bioactive peptides in Nostoc cyanobacteria, revealing interspecies communication in microbial communities.

Heliorhodopsin evolution is driven by photosensory promiscuity in monoderms

This study identifies heliorhodopsins (HeRs) as a novel type-3 rhodopsin family restricted to monoderms, likely functioning as light-dependent switches for stress mitigation and metabolic regulation.

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

A freshwater radiation of diplonemids

The paper detects freshwater diplonemids in multiple lakes, finds they form a new lineage, and suggests marine diplonemid diversity may be overestimated.

Phage-centric ecological interactions in aquatic ecosystems revealed through ultra-deep metagenomics

This study uses ultra-deep metagenomics to reveal phage-centric ecological interactions in freshwater ecosystems, identifying phage genes that enhance microbial survival against grazing and showing spatiotemporal dynamics of phage and host abundances.

Evolution in action: Habitat-transition leads to genome-streamlining in Methylophilaceae (Betaproteobacteriales)

This study shows that habitat transition leads to genome reduction in Methylophilaceae microbes through gene loss and horizontal gene transfer.

Visualization of Loki- and Heimdallarchaeia (Asgardarchaeota) by fluorescence in situ hybridization and catalyzed reporter deposition (CARD-FISH)

The paper uses CARD-FISH and epifluorescence microscopy to visualize Lokiarchaeia and Heimdallarchaeia in coastal hypersaline sediments, revealing distinct morphologies for the two lineages.

The sunlit microoxic niche of the archaeal eukaryotic ancestor comes to light

The paper uses phylogenetic analyses and metabolic reconstructions to infer the lifestyle and metabolic environment of the closest archaeal relatives of eukaryotes, revealing microoxic lifestyles and novel metabolic pathways.

A Swiftian Voyage from Brobdingnag to Lilliput: Freshwater Planctomycetes drifting towards the poles of the genome size spectrum

This study uses ecogenomics to explore the evolutionary history and genome architecture of freshwater Planctomycetes, revealing niche-driven genome reduction and specialized lifestyles.

Hidden in plain sight - highly abundant and diverse planktonic freshwater Chloroflexi

The paper examines the diversity and distribution of freshwater Chloroflexi in various pelagic habitats, revealing their genomic diversity and ecological roles.

Heliorhodopsins are absent in diderm (Gram-negative) bacteria: Some thoughts and possible implications for activity

The paper examines the presence of heliorhodopsins in diderm bacteria using metagenomic data and finds they are absent, suggesting a possible role in light-driven transport of amphiphilic molecules.