MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis
V. V. Phadnis, J. Snider, V. Wong, K. D. Vaccaro, T. Kunchok, J. Allen, Z. Yao, B. Geng, K. Weiskopf, I. Stagljar, W. S. Henry, R. A. Weinberg
This paper identifies MMD as a scaffold protein that promotes ferroptosis by facilitating the synthesis of arachidonoyl-phospholipids through interactions with ACSL4 and MBOAT7.
bioRxiv · Sep 1, 2022Cell Biology