R. H. Singer

The paper shows that lysosomal amino acid release at ER junctions regulates translation of secretome mRNAs, with Lunapark and lysosomal function playing key roles.

The paper identifies that the MS2-MCP system can destabilize mRNA and introduces an improved version with minimal mRNA stability perturbation.

The paper quantifies mRNA and lncRNA transfer between human and mouse cells in co-culture, showing non-selective transfer and correlation with donor gene expression.

This study uses live-cell imaging to show that PBAF chromatin remodeler dynamically targets acetylated chromatin hubs via bromodomains, with distinct binding kinetics in euchromatin and heterochromatin.

The paper studies transcriptional bursting at the p21 gene and identifies short-term transcriptional memory (STTM) linked to p53 regulation and burst duration.

The paper uses live-cell imaging to study the dynamics of translation initiation factors at the 5' cap, revealing their temporal regulation.

The paper uses a single-cell reporter system to show cell-to-cell variability in NMD efficiency, linked to differences in SMG1 and phosphorylated UPF1 levels.

This study identifies the RNA binding specificity of IMP family proteins using SELEX and NMR, showing that variable loops determine target RNA selection and disease-related functions.

This study shows that macroH2A re-targets to heterochromatic domains in G1 phase after DNA replication, maintaining epigenetic memory through cell division.

This paper demonstrates that full-length mRNAs transfer between mammalian cells via membrane nanotubes, not extracellular vesicles, and shows this process alters the acceptor cell proteome.

The paper shows that low-affinity enhancer binding by Ubx is efficient in nuclear microenvironments with high Ubx concentration, aided by cofactor Hth.