W. Nijenhuis

This study identifies SARS-CoV-2 ORF7a as a viral factor that downregulates MHC class I surface expression, impairing antigen presentation and immune surveillance.

This paper introduces a motor-based method to induce chromosome-specific mis-segregations in human cells, revealing how spindle forces can cause aneuploidies.

This paper introduces opto-katanin, a light-activated tool for localized microtubule disassembly, enabling precise spatiotemporal control in mammalian cells.

This study shows that PCM can self-assemble into a compact MTOC in interphase cells without centrioles, using dynein transport and self-clustering, but this process is sensitive to motor and microtubule dynamics.

This study uses advanced microscopy to show how SARS-CoV-2 changes the structure of human airway cells at the subcellular level.

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

This study develops and applies a live-cell assay to observe and quantify the dynamics of aggrephagy, revealing key spatiotemporal features of autophagosome formation and cargo-driven initiation.

The paper identifies mRNAs that associate with early endosomes and shows that the coding region of EEA1 mRNA is sufficient for endosomal localization.

This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.