Author

Y. E. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Organism:non-human primate· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. R. Keeffe· 5 shared M. C. Nussenzweig· 5 shared P. J. Bjorkman· 5 shared A. A. Cohen· 4 shared A. P. West· 4 shared C. O. Barnes· 4 shared P. N. P. Gnanapragasam· 4 shared L. M. Kakutani· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersImmunology

J. R. Keeffe

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

C. Fan, A. A. Cohen, M. Park, A. F.-H. Hung, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, L. M. Kakutani, Z. Wu, K. E. Malecek, J. C. Williams, P. J. Bjorkman

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

bioRxiv · Jun 28, 2022Immunology

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

A. A. Cohen, N. A. van Doremalen, A. J. Greaney, H. Andersen, A. Sharma, T. N. Starr, J. R. Keeffe, C. Fan, J. E. Schulz, P. N. P. Gnanapragasam, L. M. Kakutani, A. P. West, G. Saturday, Y. E. Lee, H. Gao, , P. J. Bjorkman

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

bioRxiv · Mar 25, 2022 · PreprintMicrobiology

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

C. O. Barnes, T. Schoofs, P. N. P. Gnanapragasam, J. Golijanin, K. E. Huey-Tubman, H. Gruell, P. Schommers, N. Suh-Toma, Y. E. Lee, J. C. C. Lorenzi, A. Piechocka-Trocha, J. F. Scheid, A. P. West, B. D. Walker, M. S. Seaman, , P. J. Bjorkman

This paper describes a VRC01-class antibody with lower somatic mutation but comparable breadth and potency to other broadly neutralizing antibodies against HIV-1.

bioRxiv · Mar 16, 2022Immunology

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

Z. Wang, F. Muecksch, A. Cho, C. Gaebler, H.-H. Hoffmann, V. Ramos, S. Zong, M. Cipolla, B. Johnson, F. Schmidt, J. DaSilva, E. Bednarski, T. B. Tanfous, R. Raspe, K. Yao, , M. C. Nussenzweig

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

bioRxiv · Feb 1, 2022 · PreprintImmunology

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

C. A. Jette, A. A. Cohen, P. N. P. Gnanapragasam, F. Muecksch, Y. E. Lee, K. E. Huey-Tubman, F. Schmidt, T. Hatziioannou, P. D. Bieniasz, M. C. Nussenzweig, A. P. West, J. R. Keeffe, P. Bjorkman, C. O. Barnes

The paper identifies two class 4 anti-RBD antibodies from COVID-19 donors that broadly neutralize zoonotic sarbecoviruses and SARS-CoV-2 variants with high potency.

bioRxiv · Apr 23, 2021Immunology

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope

M. E. Abernathy, H. B. Gristick, J. Vielmetter, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, A. Escolano, R. Gautam, M. S. Seaman, M. A. Martin, M. C. Nussenzweig, P. J. Bjorkman

This study identifies an off-target antibody that displaces the HIV-1 Env fusion peptide and blocks neutralizing epitopes, providing insights for vaccine design.

bioRxiv · Mar 17, 2021Immunology

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

A. A. Cohen, P. N. P. Gnanapragasam, Y. E. Lee, S. Ou, L. M. Kakutani, J. R. Keeffe, C. O. Barnes, H.-J. Wu, M. Howarth, A. P. West, M. C. Nussenzweig, P. J. Bjorkman

The paper demonstrates that mosaic nanoparticles displaying multiple coronavirus RBDs induce cross-reactive and neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses in mice.

bioRxiv · Nov 17, 2020Immunology