K. Yao

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection

This study compares memory B cell responses after Delta and Omicron BA.1 breakthrough infections versus mRNA vaccine doses, finding that Delta infection boosts overall memory B cell potency and breadth, while Omicron infection only enhances strain-specific responses.

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

Identifying Upper Airway and Evaluating Adenoid in Lateral Cephalometric Radiographs of Pediatric Patients Using Image-based Deep Learning Technique

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

CTRL: a label-free method for dynamic measurement of single-cell volume

CTRL measures single-cell volume dynamically using label-free deep learning and fluorescence exclusion from DIC images, revealing reduced cell size fluctuations during the cell cycle.

A putative microcin amplifies Shiga toxin 2a production of Escherichia coli O157:H7

This paper identifies a microcin produced by E. coli 0.1229 that enhances Shiga toxin 2a production in E. coli O157:H7 through a mechanism involving the SOS response.

Cell Type Classification and Unsupervised MorphologicalPhenotype Identification from Low-Res Images with DeepLearning

This paper develops a deep learning method for cell type classification and unsupervised morphological phenotype identification from low-resolution images.

YAP/TAZ as a Novel Regulator of cell volume

This study identifies YAP/TAZ as regulators of single-cell volume, showing their role extends beyond cell cycle duration and shape, and they influence division volume independently of mTOR.

Retrospective whole-genome sequencing analysis distinguished PFGE and drug resistance matched retail meat and clinical Salmonella isolates

This study used whole-genome sequencing to compare retail meat and clinical Salmonella isolates, revealing genetic differences and antimicrobial resistance patterns.

PGC-1α coordinates with Bcl-2 to control cell cycle in U251 cells through reducing ROS

The paper shows PGC-1α and Bcl-2 work together to reduce ROS and delay cell cycle progression in U251 cells after serum depletion.