DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing N6-methyladenosine binding
M. Li, J. Li, A. Yuan, W. Dong, S. Dong, Y.-G. Yang, Y. Wang, C. Wu, J. Li
This study shows that DNA damage-induced O-GlcNAcylation of YTHDC1 enhances its m6A binding, promoting homologous recombination and genome stability.
bioRxiv · Sep 3, 2022Biochemistry