Luis Martínez‐Sobrido

This study presents a 2.4 Å crystal structure of the SARS-CoV-2 nsp16/nsp10 complex bound to Cap-1 RNA, revealing structural insights into its assembly and methylation mechanism.

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

This paper develops a live attenuated vaccine candidate, LPhTXdNS1, against H5N1 influenza viruses and shows it is safe, immunogenic, and protective in mice.

This study identifies amino acid changes in the PB2 protein of H5N1 HPAIV that enhance replication and pathogenicity in human cells and mice.

This study assesses serological protection against H5N1 and H7N9 avian influenza viruses and evaluates the effectiveness of seasonal flu vaccines in inducing protective immunity.

This study compares replication and pathogenicity of cattle-origin H5N1 influenza viruses in mammals and birds, finding higher replication efficiency and pathogenicity in human-adapted isolates.

This paper develops replication-competent reporter-expressing Rift Valley fever viruses to track viral infection and study genome plasticity.

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

This study shows that NMT inhibition reduces mammarenavirus replication by impairing Z protein budding and GP2 fusion activity.

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

This study shows the Omicron BA.1 Spike protein reduces SARS-CoV-2 virulence in a feline model by impairing viral spread and causing less severe disease.

This study shows that PKR activation can both restrict and enhance LCMV replication, revealing a complex role for PKR in mammarenavirus infection.

This study shows that mutating the SARS-CoV-2 NSP3 Mac1 domain reduces viral replication and pathogenesis in vivo.

This study evaluates 19 compounds for antiviral activity against Orthopoxviruses, identifying 13 with activity against vaccinia virus and 11 with activity against monkeypox virus.

This paper develops a method to generate human alveolar macrophage-like cells in vitro using lung lipids and cytokines, enabling study of lung inflammatory diseases and infections.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

The paper shows that SUPT16H, a FACT subunit, interacts with BRD4 to suppress antiviral interferon signaling, and its inhibition enhances IFN responses against multiple viruses.