Paul Robson

This study uses high-resolution spatial transcriptomics to map fibroblast and neuroimmune microenvironments in endometriosis lesions, identifying spatial cellular interactions linked to pain.

Open-source STAR binary for five transcriptomic assays runs 3.9- to 6.2-fold faster than Cell Ranger 9.0.1 for scRNA-seq and Perturb-seq, 17- to 41-fold for Flex, with closely concordant counts.

The paper maps the spatial distribution of voltage-gated ion channels in mouse mammillary bodies using FISH and links it to molecularly defined neuronal populations.

DIANNE enables rapid training and inference of spatial differential attributes in histology images without manual annotations, using mixup augmentation and foundation models.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

The paper introduces SparTile, a computational method for analyzing multiplex proteomics images to identify clinically relevant spatial microenvironments in TNBC, finding specific markers and distances associated with poor survival.

spCorr identifies spatially varying gene correlations in spatial transcriptomics data, revealing biologically meaningful patterns and improving detection power while controlling FDR.

This study identifies immunosuppressive mechanisms in osteosarcoma using single-cell and spatial transcriptomics, revealing interactions between MDSCs, T-cells, and tumor cells that promote an immunosuppressive microenvironment.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

The paper uses single-cell RNA sequencing to analyze RPE cell heterogeneity in mice, identifying six cell populations and changes in gene expression during maturation.

This study uses single-cell transcriptomics to analyze endometriosis, identifying novel cell types and mechanisms in both eutopic and ectopic tissues.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

This paper defines the cellular composition of the mouse urinary bladder using single-cell profiling and spatial analysis, identifying novel cell types and fibroblast populations associated with aging.

The paper uses scRNA-seq to classify cell types in the mouse ventral posterior hypothalamus, revealing distinct neuronal and non-neuronal populations and their spatial organization in the mammillary bodies.

This study uses single-cell transcriptomics to show estrogen signaling enhances the mitochondrial folate pathway, supporting purine and polyamine synthesis in breast cancer cells.

The paper quantifies Sox2 and Oct4 synergistic binding to Sox/Oct motifs, showing Sox2 levels drive Fgf4 expression, influencing cell fate decisions in mouse embryos.

This study profiles 22,469 human kidney cells to identify 27 cell types, novel markers, and interactions, highlighting endothelial cell roles in kidney disease.

CellView provides an interactive web tool for exploring high-dimensional single cell RNA-seq data to enhance biological insights.