Mark Phillips

This study investigates how pool size and biological replication affect metabolomic signal detection and reproducibility in Drosophila melanogaster.

This study shows that genetic variation persists under intense directional selection in Drosophila and can be rapidly redeployed when selection reverses, suggesting balancing-selection maintains this variation.

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

This study compares genetic variation in synthetic recombinant Saccharomyces cerevisiae populations created by pairwise crossing versus mixing parental strains, finding that crossing increases initial genetic variation and adaptive potential.

This study investigates the genetic basis of Drosophila melanogaster's defense against Beauveria bassiana using QTL mapping and evolve and resequence approaches, revealing genetic variation and trade-offs in immune defense.