Brian C. Glancy

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

This paper provides a comprehensive protocol for quantifying cellular organelles using light microscopy and Fiji/ImageJ, enabling precise, high-throughput, and statistically comparable measurements across different samples.

The paper validates a method to quantify 3D mitochondrial network morphology in mouse skeletal muscle and applies it to terminal Schwann cells, showing increased fragmentation in dystrophic muscle.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study shows that overexpressing ChR2-EYFP in skeletal muscle causes contractile dysfunction, while ChR2-only mice show normal function, highlighting the need for alternative optogenetic models.

This study examines changes in myofibril size, shape, and connectivity in aging muscle across mice and humans, finding increased connectivity and variable size/shape changes depending on muscle type.

The paper compares mitochondrial structure and function in skeletal muscle based on proximity to capillaries or sarcolemma, finding capillary proximity enhances energy conversion and distribution.

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.