Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine
K. W. Peng, T. Carey, P. Lech, R. Vandergaast, M. A. Munoz-Alia, N. Packiriswamy, C. Gnanadurai, K. Krotova, M. Tesfay, C. Ziegler, M. Haselton, K. Sevola, C. Lathrum, S. Reiter, R. Narjari, B. Balakrishnan, L. Suksanpaisan, T. Sakuma, J. Recker, L. Zhang, S. Waniger, L. Russell, C. Petro, C. A. Kyratsous, A. Baum, , S. J. Russell
Abstract
An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.
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