Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire
The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.
bioRxiv · Oct 11, 2022Biophysics
K. Gayvert, R. Copin, S. McKay, I. Setliff, W. K. Lim, A. Baum, C. A. Kyratsous, G. S. Atwal
The paper analyzes SARS-CoV-2 genomic diversity to identify sites under selection, showing purifying selection dominates with some diversifying pressure, particularly in the spike protein and T cell epitopes.
bioRxiv · Dec 30, 2021 · PreprintEvolutionary Biology
K. W. Peng, T. Carey, P. Lech, R. Vandergaast, M. A. Munoz-Alia, N. Packiriswamy, C. Gnanadurai, K. Krotova, M. Tesfay, C. Ziegler, M. Haselton, K. Sevola, C. Lathrum, S. Reiter, R. Narjari, , S. J. Russell
This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.
bioRxiv · Oct 16, 2021Immunology
R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous
This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.
bioRxiv · Mar 10, 2021 · PreprintMicrobiology
A. Baum, R. Copin, D. Ajithdoss, A. Zhou, K. Lanza, N. Negron, M. Ni, Y. Wei, G. S. Atwal, A. Oyejide, Y. Goez-Gazi, J. Dutton, E. Clemmons, H. M. Staples, C. Bartley, , C. A. Kyratsous
This study evaluates the efficacy of the REGN-COV2 antibody cocktail in preventing and treating SARS-CoV-2 infection in rhesus macaques and hamsters, showing reduced virus load and pathological effects.
bioRxiv · Aug 2, 2020Microbiology
L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban
This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.
bioRxiv · Jul 4, 2020Microbiology
D. K. Singh, S. R. Ganatra, B. Singh, J. Cole, K. J. Alfson, E. Clemmons, M. Gazi, O. Gonzalez, R. Escabedo, T.-H. Lee, A. Chatterjee, Y. Goez-Gazi, R. Sharan, R. Thippeshappa, M. Gough, , M
This study compares SARS-CoV-2 infection in three nonhuman primate species, showing varied disease progression and immune responses.
bioRxiv · Jun 5, 2020Immunology
R. Vandergaast, T. Carey, S. Reiter, P. Lech, C. Gnanadurai, M. Tesfay, J. Buehler, L. Suksanpaisan, S. Naik, B. Brunton, J. Recker, M. Haselton, C. Ziegler, A. Roesler, J. R. Mills, , S. J. Russell
The paper develops and validates IMMUNO-COV, a high-throughput assay that accurately quantifies SARS-CoV-2-neutralizing antibodies in human sera.
bioRxiv · May 26, 2020 · PreprintImmunology
S. Doganay, M. Y. Lee, A. Baum, J. Peh, S.-Y. Hwang, J.-Y. Yoo, P. J. Hergenrother, A. Garcia-Sastre, S. Myong, T. Ha
The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.
bioRxiv · Aug 31, 2017Biophysics