biophysical modeling

This study identifies a hetero-trimeric complex formed by Setdb1 and two Atf7IP copies that blocks Setdb1 nuclear export by competing with CRM1.

This study uses bioinformatics to screen thermophilic genomes for polyhydroxyalkanoate synthesis genes, finding them rare in extreme thermophiles but present in some archaea.

This study reveals how ascorbate regulates FODD enzyme activity and substrate selectivity, providing structural insights into its role in RNA demethylation and broader biological oxidation reactions.

The paper identifies Dip2 as a conserved regulator of DAG-based PKC signaling in eukaryotes, showing its role in maintaining specific DAG subpopulations required for PKC-mediated pathways.

The paper demonstrates that motor clustering enhances kinesin-driven vesicle transport efficiency, reducing the required number of motors for long-distance transport.

This paper identifies the LxL motif in ZIP4 as an atypical dileucine motif that mediates zinc-dependent endocytosis via AP2 and clathrin.

This study identifies a novel pathway involving CD24, aSMase, PI3K/mTORC2/ROCK/actin that regulates bioactive ectosome formation in B lymphocytes.

This study identifies distinct roles of BRCA2's two DNA binding domains in DNA repair and replication fork stability using genetic and biochemical methods.

The paper develops a biophysical model to elucidate how Spo0A[~]P binding to its regulatory boxes affects spo0A transcription in Bacillus subtilis, revealing repressive effects and the role of RNAP holoenzyme levels in expression increase.

This study determines the cryo-EM structures of PimE from Mycobacterium abscessus and elucidates its mechanism of action, providing insights for anti-TB drug development.

The paper identifies alkaline phosphatase (AP) as a widespread promiscuous enzyme capable of oxidizing phosphite, contributing to microbial phosphorus cycling.

This study uses molecular dynamics simulations to show that transient interdomain interactions in Httex1 modulate its structural ensemble and self-assembly, contributing to aggregation in Huntington's disease.

This study investigates the structure and function of a SAM-AMP lyase from Clostridium botulinum, showing its ability to substitute for a phosphodiesterase in providing anti-phage defence.

This study investigates the Zdhhc5-GOLGA7 protein complex involved in non-apoptotic cancer cell death induced by CIL56, revealing key residues critical for complex formation and cell death.

The paper investigates how extracellular K+ and Na+ ions differentially regulate TCR signaling by modulating ZAP-70 recruitment, affecting T cell function and development.

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.

The paper identifies teichuronic acid oligosaccharides as the receptor for umbrella toxins and shows targeting specificity arises from lectin domain recognition of variable TUA-WTA structures.

This study elucidates the mechanism of MBOAT-SGNH acyltransferases in Gram-negative bacteria, showing that a tyrosine-containing peptide shuttles acyl groups from MBOAT to SGNH active sites for peptidoglycan O-acetylation.

This study identifies a trade-off between PAM recognition breadth and CRISPR-Cas9 editing efficiency, proposing a two-step target capture mechanism to improve genome editing.

The paper determines cryo-EM structures of CpaF in different conformations and proposes a rotary mechanism of catalysis for Tad pilus assembly and disassembly.

The paper identifies proteins and amino acid patterns associated with iodine binding in human tissues to improve μCT imaging contrast.

This study maps the free energy landscape of K-Ras4B dimerization using simulations, revealing multiple interfaces and showing the G12D mutant forms more diverse dimers than wild-type.

This study characterizes the RNA virome of Tuta absoluta, identifying ten novel insect-specific viruses and highlighting greater viral diversity in field populations compared to lab samples.

This paper determines the structure of the palladin-actin complex using crosslinking, docking, NMR, and SAXS, revealing how palladin stabilizes F-actin at the interface between two actin monomers.

This study identifies that floral handedness in Cyanella alba is determined by phyllotactic spiral direction and auxin-induced differential cell elongation, not genetics.

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

The paper investigates whether reported miRNAs in cancer are functionally active, finding many are not incorporated into RISC and lack endogenous silencing capability.

This study investigates how environmental factors like pH and ionic strength affect the conformational and amyloidogenic properties of DPF3a using biophysical and molecular dynamics methods.

This study shows IP6 binding influences the kinetic switch of the HIV-1 capsid's TVGG motif between coil and helix conformations, essential for pentamer formation.

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.