flow cytometry

This study investigates CAR T cell cytotoxic responses, showing they are sensitive to TCR interactions and can be modulated by inhibitory peptides.

The paper develops a variational deep-learning method to model memory T cell dynamics in mice, revealing phenotypic diversity and long-term heterogeneity in lung-resident TRM cells.

A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.

This study investigates intraspecific genome size variation in Roscoea tibetica, finding environmental factors drive GS variation and smaller GS is advantageous for adaptation in alpine habitats.

This study improves NK cell transfer models in mice by showing that CRISPR-generated JAXBoy NK cells persist better than conventional BoyJ cells, and identifies roles for CXCR3 and ASCL2 in splenic NK cell localization during virus infection.

This study shows that chronic alcohol consumption increases the differentiation of hematopoietic stem and progenitor cells into osteoclast precursors, contributing to reduced bone density.

This paper develops a method to isolate male gametophyte cells from tomato using fluorescence-activated cell sorting with a double fluorescent marker line.

This study investigates age-dependent tumor-immune interactions in pediatric cancer using mouse models and patient samples, finding that pediatric tumors have distinct immune profiles and poor response to immunotherapy, which can be improved by modulating the tumor microenvironment.

This study shows that malnutrition impairs immune function and myelopoiesis in mice, which partially recovers with refeeding but does not fully restore infection resistance.

The paper uses flow cytometry to identify drugs that rapidly kill Gram-negative bacteria by targeting cell membranes, finding that Pantoprazole, Theophylline, and Zoledronic acid have cytotoxic effects.

The paper examines polyploid-diploid competition in Spirodela polyrhiza under stress and shows negative frequency-dependent growth fails to overcome competitive disadvantages.

This study shows that SIRPγ reduces effector differentiation of CD8 T cells under weak TCR signals, linking its expression to immune homeostasis and autoimmunity risk.

The paper develops ImmuneFM, a foundation model pre-trained on cytometry data for immunology, showing superior performance on eight downstream tasks with limited labeled samples.

The paper identifies CD27-IgD- regulatory B cells in renal cell carcinoma that suppress CD8+T cell responses, linking them to poor prognosis.

This study shows that DNase I treatment reduces ecDNA-driven inflammation in MPO-ANCA GN, and gene therapy enhances its therapeutic effect by extending its half-life.

This study shows that ApoE deficiency, not atherosclerosis, alters non-invariant NKT cell numbers and activation, highlighting the need to use ApoE-null mice cautiously in NKT cell research.

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

The paper evaluates humoral and cellular immune responses to Salmonella Typhi antigens in typhoid-recovered individuals, finding elevated IgA and TEMRA cells, and comparable IgG and memory B cells between groups.

This study shows that CCR4 deficiency in mice worsens early atherosclerosis by impairing Treg function and promoting proinflammatory Th1 responses.

The paper examines the association between CMV-specific effector T cell subtypes, age, CMV serostatus, and systolic blood pressure in an elderly cohort.

This study investigates how pulmonary macrophage subsets respond metabolically to polarizing stimuli in vivo, revealing distinct metabolic profiles between alveolar and interstitial macrophages.

This study shows that HLA-G1 overexpressed MSCs improve heart function after myocardial infarction by enhancing cell engraftment and modulating immune responses.

This paper presents a nanovial-based platform for high-throughput functional screening of CAR T cell libraries, identifying CAR constructs with distinct secretion profiles over time.

The paper identifies early T and NK-cell dysfunction in dengue patients that predicts severe disease, with obesity exacerbating these signatures.

This study uses CRISPR, Tocky, and machine learning to analyze Foxp3 transcription dynamics in mice, revealing CNS2-dependent regulation and age-related expression patterns.

This study examines immune remodeling after aHSCT in RRMS patients, finding lineage-specific changes in T and B cells rather than full immune restoration.

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

This study identifies a novel Sca1pos neutrophil subset with pro-inflammatory properties in both steady state and inflammatory conditions.

This paper introduces capped nanovials as a scalable platform for single-cell and small colony culture, enabling high-throughput screening of growth and function with improved signal-to-noise ratios and co-culture capabilities.