T-cell and B-cell Immunology

The paper analyzes single B cell data from human tissues to show lineage co-localization and uniform differentiation rates, providing a model for antibody memory formation.

This study uses single-cell lineage tracing to show that CD8 T-cell clones exhibit differential fate commitment during acute infection, with some clones adopting memory or effector biases over time.

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

This study shows that DNA methylation via UHRF1 is essential for iTregs to promote lung recovery after viral pneumonia.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

The paper identifies novel stages in IgG memory B cell and antibody-secreting cell differentiation by analyzing antigen-specific B cells from different pathogens using high-dimensional flow cytometry.

This study uses Monte Carlo simulations to show that TCR clustering and NP geometry affect the sensitivity-specificity trade-off in T cell responses to pMHC-coated nanoparticles.

This study compares memory CD8 T cells generated from tumor rejection and acute viral infection, finding that tumor-induced cells show persistent functional defects similar to exhaustion.

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

This study determines the cryo-EM structure of the Themis-Grb2 complex, revealing its role as a dynamic structural hub in T cell receptor signaling and its functional importance in T cell development.

SeQuoIA is a single-cell BCR sequencing pipeline that tracks selection mechanisms in germinal centres by inferring BCR-driven selection pressure from somatic mutation patterns.

This study shows that exhausted T cells can form functional memory T cells after antigen clearance, and checkpoint blockade expands these memory clones.

The paper identifies a Dapl1+ subset of naive CD8 T cells that are pre-programmed to differentiate into memory-like T cells.

This study shows that recent thymic emigrants are preferentially recruited into the memory pool during persistent CMV infection, while mature CD8+ T cells contribute little.

APMAT analysis links CD8 T cell receptors, cognate antigens, and T cell phenotype/persistence using integrated experimental-computational methods.

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

This study shows overexpressing GITRL on BDL B cells increases Treg numbers and reduces EAE severity in mice, suggesting a therapeutic strategy for autoimmunity.

This study compares transcriptional profiles of memory T cells in infants and adults to identify age-specific regulatory mechanisms.

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

This study identifies phosphoglycerate mutase (PGAM) as a regulator of Treg differentiation through serine synthesis and one-carbon metabolism, showing its impact on immune suppression and autoimmunity.

The paper identifies lytic IFNγ stored in granzyme B-containing cytotoxic granules and co-secreted with GzmB by effector CD8⁺ T cells during immunological synapse formation.

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

This study identifies unconventionally primed TFH1 cells as essential for generating IgA+ long-lived plasma cells during mucosal viral infections.

This study shows that persistent antigen is necessary for maintaining Leishmania-specific memory CD4+ T cells and long-term immunity.

This study identifies IL-23's role in shaping the functional plasticity of human MAIT cells, revealing its impact on autoimmunity and cytotoxic functions through AP-1 transcription factors.

This study identifies miR-130b and its GUGCA seed motif as regulators of B cell tolerance, revealing ERalpha as a female-specific checkpoint that influences autoimmunity.

The paper investigates how spatial location influences the functional diversity of memory CD8 T cells by analyzing their transcriptomes in the small intestine.