Tuberculosis Research and Epidemiology

The paper identifies compensatory mutations in Mycobacterium tuberculosis associated with increased in vitro growth in resistant strains, highlighting their role in resistance spread.

This study examines rifampicin tolerance in isoniazid-resistant Mycobacterium tuberculosis isolates, finding increased tolerance and faster growth in resistant strains, which may contribute to multidrug-resistant TB emergence.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.

The paper models M. bovis infection dynamics in three French badger populations and develops monitoring indicators based on Bayesian prevalence analysis and simplified regression models.

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

The paper shows that Mtb's response to cholesterol, pH, and potassium is coordinated via the Mce3R regulator, with mce3R deletion reducing colonization in mice.

The paper identifies MSMEG_0311 as an essential polar protein in mycobacteria involved in cell wall metabolism, showing growth defects and altered morphology upon its repression.

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

This paper develops fluorinated trehalose analogues to label and visualize Mycobacterium tuberculosis, showing their uptake correlates with substrate recognition and enabling pathogen-specific detection.

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

This study identifies PhoR as a dual-function sensor kinase/phosphatase in M. tuberculosis, revealing its role in virulence through pH and salt sensing and regulation of the PhoP regulon.

This paper develops a method to study mycobacteria exit strategies using 3D-correlative light and electron microscopy with improved cell adhesion.

The paper identifies two non-canonical L-cysteine synthases in Mtb, CysM and CysK2, which support divergent biosynthetic pathways critical for redox stress response and survival during infection.

This study integrates multi-omics data from bovine and human macrophages infected with M. bovis and M. tuberculosis to identify genes and pathways associated with resistance to mycobacterial infection.

This study investigates ESAT-6's self-association under acidic conditions and shows an ESAT-6-specific nanobody inhibits M. tuberculosis growth in macrophages.

The paper investigates synthetic lethality in Mycobacterium tuberculosis by showing that simultaneous inactivation of Ndh-1 and Ndh-2 NADH dehydrogenases leads to bacterial death due to impaired NADH oxidation.

This paper evaluates a modified BPaL regimen replacing linezolid with inhaled spectinamide 1599 for tuberculosis treatment, showing similar efficacy while avoiding linezolid-associated adverse events.

The paper evaluates contezolid as a potential replacement for linezolid in combination with bedaquiline and pretomanid in a murine tuberculosis model, finding comparable activity and no cross-resistance.

This study compares the effects of benzothiazinone (BTZ) and ethambutol (EMB) on the corynebacterial cell envelope, showing BTZ preserves membrane integrity while EMB disrupts it.

The paper reports a case of prolonged survival in an HIV-co-infected patient with MDR-TB, linked to a unique genomic deletion in the Mtb strain.

This study identifies preferential differential gene expression in WC1.1+ γδ T cells from cattle naturally infected with Mycobacterium bovis, highlighting immune-related functions.

fastlin rapidly and accurately types Mycobacterium tuberculosis complex lineages from sequencing data, detecting mixed-lineage strains and estimating proportions.

The paper identifies drug-resistant minority variants in Mycobacterium tuberculosis populations and shows their association with mixed strain populations and treatment outcomes.

The paper examines transmission rates of borderline and common rpoB mutations in MDR-TB isolates from Bangladesh, finding no difference in transmission clustering between mutation types.

The paper evaluates DNA decontamination methods and a new target enrichment protocol to improve Mycobacterium tuberculosis whole-genome sequencing from direct patient samples.

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

This study identifies OSBP8 as an ER-dependent lipid transfer protein involved in membrane repair of mycobacteria-induced vacuole damage, which is critical for host defense against M. tuberculosis.

This paper develops DrPRG, a tool for predicting drug resistance in Mycobacterium tuberculosis using reference graphs, showing improved sensitivity and specificity compared to existing methods.