Asthma and respiratory diseases

Circadian and Sex-Specific Responses to Alternaria alternata in Allergic Airway Inflammation

This study shows that circadian timing and sex influence allergic airway inflammation caused by Alternaria alternata, with distinct temporal patterns in male and female mice.

A repair-associated bronchial epithelial differentiation trajectory through KRT14+ basal and hillock-like cells drives airway inflammation and remodelling in childhood-onset asthma

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

High-Dimensional Immunophenotyping Identifies Circulating Immune Signatures Associated with FeNO-Defined Asthma Phenotypes

This study identifies distinct systemic immune signatures in asthma patients based on FeNO levels using high-dimensional immunophenotyping.

Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts

The paper shows that inhibiting apoptosis of alveolar myofibroblasts (AMFs) reprograms them into ductal myofibroblasts (DMFs) in a mouse model, suggesting fate plasticity in lung mesenchymal cells.

The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

A Mixed T2/T17-Associated Systemic Immune Signature Links Airborne Pollutant Exposure to Persistent Respiratory Symptoms

The paper identifies a T2/T17 immune signature in individuals with persistent respiratory symptoms linked to airborne pollutant exposure and small-airway dysfunction.

Allergen-responsive T helper type 2 cells revealed by high-dimensional profiling in allergen challenged human airways

This study identifies allergen-reactive Th2 cells in human airways using high-dimensional profiling and shows their systemic expansion following allergen challenge.

Asthma Exacerbations: Integrative Analysis of miRNA Activity Using Single-Cell Transcriptomics

The paper identifies cell types regulated by circulating miRNAs linked to asthma exacerbations using scRNA-seq and validates findings in GEO datasets.

The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease

This study shows the club cell circadian clock regulates time-of-day-dependent leukocyte trafficking and airway barrier integrity in chronic allergic airways disease.

Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation.

The paper uses imaging mass cytometry to analyze ECM composition in mouse models of allergic airway inflammation, identifying distinct matrix environments associated with different cell types and tissue regions.

Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthma

This paper develops a multimodal framework to prioritize causal genes in childhood-onset asthma by integrating GWAS, bulk eQTL, and single-cell eQTL data, revealing key immune and metabolic genes and improving risk prediction across cohorts.

FcϵRI+IgE+ monocytes are linked to atopy and allergic inflammation with distinct phenotypes and enhanced antiviral responses

Genetic susceptibility to obesity-related asthma and its modulation by sequelae of obesity

The paper identifies genetic susceptibility markers for obesity-related asthma in children, showing some associations are weakened by obesity-related factors.

Characterisation of Peripheral Blood B Cell Receptor Repertoire in Severe Eosinophilic Asthma and EGPA

This study characterizes B cell receptor repertoires in severe eosinophilic asthma and EGPA, finding increased IgG4 and other subclasses, shared clones, and treatment-related changes.

Biologic therapy is associated with selective changes in airway eosinophil subpopulations in severe asthma

This paper shows biologic therapy in severe asthma reduces a specific activated eosinophil subpopulation linked to worse asthma control and lung function.

NO modulates human airway smooth muscle function by altering glucose-6-phosphate dehydrogenase effects on sGC function in asthma

This study shows that NO modulates airway smooth muscle function in asthma by altering G6PD effects on sGC function through redox regulation and heme-maturation.

Polygenic risk scores associate with asthma phenotypes and proteomic analyses implicate IL1R1 in two family-based studies

This study uses polygenic risk scores and proteomic analysis to identify genetic and molecular associations with asthma in two family-based cohorts, highlighting IL1R1's role in asthma pathogenesis.

Adipose tissue as a site of immune activation and dysfunction in individuals with obesity and asthma

The paper identifies immune cell dysfunction in adipose tissue of individuals with obesity-associated asthma using single-cell RNA sequencing.

HuR Regulates GATA3-Driven Type 2 Inflammation in CD4⁺ T cells and ILC2 in Airway Inflammation

This study identifies HuR as a regulator of GATA3-driven type 2 inflammation in asthma, showing its inhibition reduces lung inflammation and Th2 cytokine production.

Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa

The paper examines microbiome diversity and immune interactions in airway mucosa of healthy and asthmatic individuals, finding associations between bacterial counts and immune network eigenvectors.

Muc5ac mediates anti-viral immunity and virus-induced parasympathetic nerve dysfunction

This study shows Muc5ac is critical for antiviral defense but also necessary for virus-induced airway hyperresponsiveness in mice.

MicroRNA signatures of equine asthma endotypes in serum and bronchoalveolar lavage fluid

This study identifies miRNA biomarkers in equine asthma endotypes using serum and BALF samples, showing differential expression in specific endotypes and potential involvement in inflammatory pathways.

Profiling Peripheral Blood with an Optimized, Multiplexed, Single-cell Multiome Approach Supports an Insulin-driven Asthma Subtype

The paper uses a multiplexed single-cell multiome approach to identify a molecular signature of insulin-driven asthma in adults with high early-life insulin levels.

Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

This study shows that nociceptor neurons contribute to pollution-induced neutrophilic asthma by enhancing TRPA1 sensitivity and artemin release, which drives neutrophil recruitment.

Association of genetic variants in the autophagy gene ATG4B with asthma

The paper identifies genetic variants in ATG4B associated with asthma using GWAS data from the UK Biobank, showing significant associations in the discovery dataset and nominal replication.

The metabolic reprogramming of T cells controls airway remodeling in severe asthma

This study identifies OXPHOS and LIGHT as key drivers of Th17 cell metabolism and airway remodeling in MGA, showing their dual blockade can reverse disease features.

Shared genetic factors between lung function and asthma by age at onset

This study identifies shared genetic factors between asthma and lung function that vary by age-at-onset, highlighting distinct mechanisms for early-onset asthma.

Ovarian Hormones and Obesity Drive Th17-mediated Airway Inflammation through Estrogen Receptor Signaling

This study shows that estrogen receptor-alpha signaling in T cells increases Th17-mediated airway inflammation in obese female mice and that Th17 cells are more frequent in women with asthma compared to men.

Testosterone alleviates inflammation but increases the methacholine response in mice with allergic lung inflammation

This study examines how testosterone affects allergic lung inflammation in mice, finding it reduces inflammation but increases airway responsiveness to methacholine.

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

This study identifies IL-1RAP as a target for reducing eosinophilia in allergic fungal airway disease using a mouse model of chronic A. fumigatus exposure.