HIV Research and Treatment

This study shows PARP-1 deficiency or inhibition increases HIV-1 replication in human CD4+ T cells by enhancing viral infectivity and virion-associated Env levels.

This study investigates how Importin beta-1 packaged in HIV-1 virions affects viral infectivity and transcription, revealing its dual role as both a facilitator and restriction factor.

This study compares HIV-1 virion maturation and infectivity between Jurkat and HEK293T cells using a FRET-based assay, finding lower maturation and infectivity in Jurkat-derived virions.

This study shows that SETD2 inhibition reduces HIV gene expression and latency by altering viral RNA splicing, not transcription.

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

This study compares glycosylation, infectivity, and neutralization sensitivity of SIV produced in macrophages versus CD4+ T cells, revealing differences in glycan profiles and their impact on viral spread and antibody neutralization.

This study identifies the mitotic deacetylase complex (MiDAC) as a host factor that binds the HIV-1 core promoter and regulates Tat-activated transcription and latency.

This study examines how antiretroviral treatment affects immune responses in the brain and blood of EcoHIV-infected mice, identifying treatment-induced changes in cytokine and chemokine expression.

The paper redesigns hypervariable loops in HIV-1 Env consensus sequences to enhance antibody binding and improve vaccine antigen design.

This study uses HIV-guided CRISPR to identify antiviral factors by analyzing sgRNA enrichment during viral replication.

This study shows that monocyte-to-macrophage differentiation and redox changes influence HIV latency differently in cell types, with macrophages being more responsive to redox modulators.

The paper introduces a triple tandem trimer (TTT) design for HIV-1 Env and influenza HA immunogens, showing improved trimer-specific immune responses in viral vectored vaccines.

This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

The paper uses machine learning to analyze HIV reservoir and immunology data to identify immune signatures associated with total and intact HIV DNA levels during ART.

The paper shows that myristoyl exposure in M-PMV matrix protein triggers structural changes leading to efficient cleavage of Gag polyprotein.

HIHISIV is a database that integrates and provides tools to analyze gene expression data from HIV and SIV host immune responses in humans and nonhuman primates.

This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.

The paper introduces HIV-Tocky, a reporter system using a fluorescent Timer protein to visualize HIV-1 provirus expression dynamics and identifies two latent subsets of proviruses.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.

This study examines changes in immune checkpoints and senescence markers in HIV-positive individuals post-COVID-19 infection, finding elevated levels of several biomarkers in those previously infected.

This study examines how different amino acids at position 332 of HIV-1AD8 gp120 affect viral sensitivity to antibodies, cold exposure, and infectivity.

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

This study shows HIV-1 integrates near R-loops in the host genome, linking viral integration to R-loop formation and suggesting new therapeutic strategies.

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

The paper introduces a high-throughput microwell outgrowth assay to quantify and characterize HIV-infected cells with high sensitivity and precision.