DNA Repair Mechanisms

This study investigates how UV radiation induces reorganization of the 3D genome and its role in DNA damage response and repair.

The paper identifies a conserved, disordered domain in SYP-4 that regulates crossover assurance and interference in meiosis by recruiting an E3 ligase.

This study shows BRCA1-deficient breast cancers are highly sensitive to gemcitabine, leading to ssDNA accumulation and mitotic catastrophe, which may enhance antitumor immune response.

The paper uses proteomics to analyze protein dynamics during replication origin firing in human cells, identifying NCAPH2 as a novel factor required for efficient origin firing.

This study shows that phosphorylation-dependent WRN-RPA interaction is essential for replication fork recovery after stalling at secondary DNA structures, preventing DNA damage and G4 accumulation.

The paper identifies RAD54L2 as a regulator of recombination by showing its interaction with the BTRR complex and its role in suppressing sister chromatid exchanges.

This paper uses cryo-EM to determine the structure of Rad51-ssDNA filaments in budding yeast, revealing local structural dynamics and conformational changes in Rad51 protomers.

The paper investigates DNA replication dynamics in Xenopus, identifying two replication modes with distinct fork speeds and origin firing rates, and shows Plk1's role in coordinating these processes.

This study investigates how the BRCA1-BARD1 complex interacts with phosphorylated RNAPII CTD through BRCT repeats, revealing its role in RNAPII condensation and transcription-DNA repair coordination.

This study shows that Condensin II in Arabidopsis is essential for resisting genotoxic stress and proper chromatid resolution during mitosis.

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

This study shows that Mlh1-Pms1 uses ATP to compact and remodel DNA, which is important for mismatch repair and genome stability.

The paper identifies a novel phosphorylation motif in Tel1 signaling that expands the understanding of its role in DNA repair and telomere control.

This paper reviews the role of Rad5 in telomere replication and its connection to the DNA Damage Tolerance pathway in yeast.

This study quantifies how DNA damage, specifically DSBs and nicks, leads to chromosome loss in minichromosomes, contributing to aneuploidy.

This study uses live-cell microscopy to analyze PCNA and RPA1 dynamics during replication fork stalling and restart in response to hydroxyurea, revealing distinct processes and the role of ATR in fork restart.

This study shows that DNA polymerase δ proofreading nuclease inhibits translesion synthesis and promotes recombination during DNA lesion bypass.

The paper identifies genes critical for the replication stress response in human cells, revealing both known and novel factors that protect against replication stress-induced toxicity.

This paper introduces O6-MeG-seq, a method to map O6-methylguanine at single-nucleotide resolution, and shows MGMT does not preferentially repair O6-MeG based on sequence context or chromatin state.

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

This study shows the PST repeat region of MDC1 is a multivalent chromatin tethering domain with tunable affinity that aids in DNA break tethering during HR and mitosis.

The paper shows that DNA-binding activity alone of Msh2-Msh3 is insufficient to promote trinucleotide repeat expansions in yeast.

The paper investigates the functional roles of the N-terminal intrinsically disordered region of Bloom Syndrome helicase in Drosophila by deleting conserved regions and assessing their impact on DNA repair and meiotic processes.

This study reconstitutes human DNA licensing, analyzes its intermediates, and identifies how cancer mutations disrupt helicase loading.

The paper shows that Sir2 suppresses transcription near arrested replication forks in yeast rDNA to prevent copy number changes by directing DSB repair away from HR.

This study shows that polymerase Eta's PIP and UBZ domains are critical for managing replication stress at common fragile sites by recruiting FANCD2 and preventing DNA damage.

The paper investigates the distinct and interdependent roles of three RING proteins in regulating meiotic recombination in mice, revealing their unique spatiotemporal dynamics and functional relationships.

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

The paper identifies two novel components, UpsC and CedD, involved in DNA repair mechanisms in Sulfolobus acidocaldarius through genetic analysis and functional assays.