Circadian rhythm and melatonin

This study identifies circadian rhythmic transcripts in mouse astrocytes and shows that circadian regulation of ER Ca2+ release affects gap junction communication and synaptic activity.

The paper evaluates melanopsin reporter systems for labeling retinal ganglion cells and finds no method labels all and only intrinsic photosensitive retinal ganglion cells.

This study investigates diurnal variation in human SCN activity using perfusion imaging, finding higher activity at noon and lower in the early morning, aligning with rodent patterns under light conditions.

This study investigates how thyroid hormone levels affect liver circadian transcriptome rhythms in mice, identifying 516 genes as molecular markers of liver TH state.

This study shows that intrinsic skeletal muscle function and contraction-stimulated glucose uptake in mice do not vary across the 24-hour circadian cycle.

This study shows metadichol increases expression of CRY1, CLOCK, and PPARGC1A in human fibroblasts, but not PER1 or BMAL1, suggesting indirect effects on circadian clock genes.

This study compares seven algorithms for detecting differential rhythmicity in transcriptomic data, finding high overlap in results but differences in output numbers and parameters.

This paper extends a biochemical model of circadian rhythms to include mechanical effects, showing that mechanical signals must be within an optimal range for oscillations to occur.

This study shows that light suppresses melatonin differently in young and older adults, with young adults relying solely on melanopsin and older adults involving L-cones as well.

This paper introduces a model to distinguish between endogenous and exogenous factors affecting sleep timing using longitudinal data and personalized mathematical modeling.

This study investigates the impact of blue-yellow light changes on the human circadian clock and sleep, finding no significant effects under moderate light levels.

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

LimoRhyde2 analyzes genomic data to identify rhythmic genes by focusing on effect sizes rather than statistical significance, revealing genes with high-amplitude rhythms.

This study identifies TARANIS as a novel regulator of the Drosophila circadian clock by enhancing the transcriptional activity of VRILLE and PDP1.

This study shows that P2-HNF4 regulates ketogenesis in the liver and is involved in circadian metabolism, with implications for gender-specific ketone body levels.

This study examines how diabetes affects the daily rhythmic gene expression in retinas, finding phase shifts in the transcriptional cycle linked to metabolic and hypoxia pathways.

This study shows that diurnal light cycles drive rhythmic physiology in facultative phototrophic bacteria, enhancing survival under nutrient limitation.

This study examines how different light levels affect task-evoked pupil responses during cognitive tasks, finding that higher light levels increase pupil dilation in response to auditory stimuli.

This study examines how lithium affects honey bee locomotor activity and circadian rhythms, finding that it alters activity levels and disrupts circadian patterns, similar to its effects in bipolar disorder treatment.

This study resolves conflicting models of melanopsin phototransduction in ipRGC subtypes, showing HCN channels are dispensable in M4 and M2, with TRPC and T-type calcium channels playing key roles.

This study shows that SCN neurons maintain circadian rhythms at moderate hypothermia but suspend them at deep hypothermia, with Ca2+ rhythms resetting faster than transcriptional rhythms upon rewarming.

This study shows that Lake Malawi cichlid activity patterns change with ontogeny and social context, with juveniles showing more robust rhythms than adults, which can be restored through social interactions.

The paper investigates how repeated short light exposures affect sustained pupil responses during different cognitive tasks, finding that higher melanopic irradiance increases pupil responses and that task context influences variability.

This study identifies a marine cryptochrome, PdLCry, that undergoes inverse photo-oligomerization compared to plant CRYs, enabling light intensity discrimination for lunar cycle synchronization.

The paper identifies genetic variants and expression changes in circadian genes and BDNF associated with post-stroke cognitive impairment in Eastern Indians.

This paper introduces a bioelectronic system for circadian neuromodulation that adjusts therapy based on the sleep/wake cycle, showing effectiveness in two patient phenotypes.

This study examines the spatio-temporal dynamics of nuclear CREB1 in rat pinealocytes, finding that its distribution varies across time and cell types, with increased dispersion at night.

This paper introduces ODeGP, a Gaussian Process-based method for detecting oscillations in time series, and shows it outperforms existing methods in detecting weak and non-stationary rhythms in qPCR data.

CIRCUST reconstructs temporal order of molecular rhythms from single timepoint data, validated on controlled experiments and applied to GTEx tissues to build a human daily rhythm gene expression atlas.

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.