Muscle Physiology and Disorders

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

This study identifies DUSP22 as a novel target for preventing skeletal muscle wasting by repressing the JNK-FOXO3a pathway independently of Akt.

This study shows GL261 glioblastoma tumors in young mice reduce skeletal muscle growth, mass, and protein synthesis while altering catabolism signaling.

This study shows that muscle fiber Myc is not required for muscle growth but its overexpression disrupts muscle structure and function.

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

This study identifies bazedoxifene as a potential treatment for LGMD R2 through high-throughput screening of drugs targeting dysferlin aggregation.

This study investigates BMD mice with specific exon deletions, showing site-specific muscle degeneration, type IIa fiber reduction, and capillary changes linked to nNOS reduction.

This study investigates whether muscle-specific Keap1 deletion prevents inactivity-induced muscle atrophy in mice, finding it enhances force production but does not prevent atrophy or weakness after hindlimb unloading.

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.

This study shows that 3D mechanical confinement regulates muscle stem cell fate by maintaining stemness and inhibiting differentiation through epigenetic and nuclear changes.

This study shows engineered human myogenic cells in hydrogels form functional myofibers in dystrophic mouse muscle, producing dystrophin and integrating with host nerves and blood vessels.

This study shows that adding human iPSC-derived motor neurons to engineered muscle bundles improves their structural and functional maturity and maintains an oxidative phenotype.

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

The paper identifies transcription factors regulating gene expression in human soleus and vastus lateralis muscles before and after disuse, finding distinct responses and associations with inflammation and mitochondrial metabolism.

This study identifies a pro-myogenic domain in CYTOR and shows that chemically modified RNA delivery improves dystrophic myotube function.

This study shows that a diet enriched with deuterium-reinforced polyunsaturated fatty acids (D-PUFA) prevents muscle atrophy and weakness in STZ-induced diabetic mice.

This study examines how injury size affects immune cell dynamics in muscle repair, finding early macrophage dysfunction and increased neutrophils in fibrotic outcomes.

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

This study shows that a sedentary lifestyle in rats leads to oxidative stress and muscle atrophy in the soleus muscle.

This study shows that Fn14 regulates satellite cell self-renewal and expansion during skeletal muscle repair, with implications for treating muscular disorders.

This study investigates MEGF10's role in myoblast fusion and muscle hypertrophy, finding that it inhibits fusion and promotes satellite cell adhesion and survival.

This study examines how resistance training status affects muscle size and molecular markers during leg immobilization and recovery training in young adults.

This study examines how chemically-induced ovarian failure affects muscle fibre contractility in mice, finding increased force and changes in fibre type proportions over time.

This study develops scaffold-free 3D in vitro models of muscular dystrophies using patient-specific cells, showing they closely mimic in vivo conditions and respond to therapeutic drugs.

The paper examines differences in mononuclear cells and myonuclei at human myofibre tips, finding more mononuclear cells and COL22A1-expressing nuclei in type II fibres compared to type I.

This study shows that Wnt7a is critical for muscle regeneration in dystrophic mice, and systemic delivery of Wnt7a-containing extracellular vesicles can rescue regeneration deficits.