Microtubule and mitosis dynamics

This study shows that Bicaudal-D is essential for female meiosis II and pronuclear fusion in Drosophila, by localizing key proteins to the meiosis II spindles.

This study shows that S. cerevisiae cells can survive without Pds5 if Mcd1 levels are increased and SUMO-PCNA is elevated, revealing Pds5's role in cohesin stability and DNA replication coordination.

The paper characterizes mutations in C. elegans Haspin homologs, showing hasp-1's roles in germline stem cell proliferation, spermatogenesis, and oocyte meiosis, with genetic interactions involving plk-2 and CPC recruitment pathways.

This study uses computational and in vivo approaches to analyze the structure-function relationships of CeSPD-2, identifying new domains and motifs that may explain its functional diversity.

The paper creates a synthetic ancestral Kinesin-13 motor domain and shows it depolymerises microtubules faster than any known natural depolymerising kinesin.

This study investigates the role of spectraplkin proteins in axon growth and maintenance, revealing that their function depends on a balanced interaction with F-actin and that they have actin-independent roles in microtubule bundling.

This study shows that SAE2 deacetylation during mitosis biases SUMO2 over SUMO1 conjugation, affecting mitotic fidelity through SUMOylation of NuMA.

The paper determines the structure of dynein-dynactin complex with BICDR1 adaptor bound to microtubules, revealing adaptor recruitment mechanism and interactions.

This study identifies Poe and Hyd as E3 ligases that promote PLP degradation during spermatogenesis, ensuring proper centriole assembly and male fertility.

The paper analyzes post-translational tubulin modifications in human neural stem cells differentiated into neurons and astrocytes, finding differences in acetylated and polyglutamylated tubulin ratios between cell types.

This study investigates the sex-specific role of Topoisomerase II in sister chromatid cohesion release during meiosis in C. elegans, showing different requirements in spermatogenesis and oogenesis.

This study shows Atg11, an autophagy-related protein, regulates microtubule dynamics and chromosome segregation in yeast by affecting spindle pole body function and Kar9-dependent spindle positioning.

The paper identifies a molecular mechanism by which Patronin amplifies fusome asymmetry to select the oocyte in the female germline cyst.

The paper introduces Spindle3D, a tool for analyzing 3D spindle morphology, and finds that spindle width best predicts spindle volume across cell types and species.

The paper revisits the role of beta-tubulin60D in Drosophila development, showing it is not essential and identifying a dominant-negative mutation with tissue-specific effects on bristle morphogenesis.

This paper demonstrates that bacterial microtubules can be expressed in a cell-free system and used to deform lipid vesicles, offering a new tool for synthetic cell biology.

This study identifies OpHCD1 and OpHCD2 as kinases involved in mitotic exit and cytokinesis in Ogataea polymorpha, suggesting a SIN-like pathway regulates mitosis termination in this yeast.

This paper identifies Mask as a novel regulator of microtubule dynamics in Drosophila, showing genetic interactions with Tau and Stathmin and a role for its Ankyrin repeats domains.

The paper shows that the human sperm basal body converts to a centrosome after fertilization, supporting early embryogenesis and compaction.

This study identifies RhoA and RanGTP-dependent forces that drive symmetry breaking and spindle rotation in mouse oocytes during meiosis.

The paper measures asymmetric organelle partitioning in cancer cells and finds mitochondria and membrane lipids are asymmetrically distributed and correlated with cytoplasm apportioning.

This study identifies Msps/XMAP215 as a regulator of acentrosomal microtubule assembly in quiescent Drosophila NSCs, which is essential for E-cadherin localization and NSC reactivation.

The paper shows that Traip function during mitosis is critical for proper brain size in Drosophila, as its loss causes neuronal loss due to mitotic defects.

The paper shows that the N-terminal tail of CENP-A is required for de novo centromere establishment in C. elegans germ line but not for maintenance during embryogenesis.

This study shows that Parafibromin/Hyrax regulates cell polarity and centrosome assembly in neural stem cells, preventing overgrowth and tumour formation.

The paper identifies a release-and-capture mechanism involving Katanin and Patronin that generates a non-centrosomal microtubule array essential for tube budding in Drosophila salivary glands.

This study tests whether microtubules are involved in learning in Paramecium by disrupting microtubular dynamics and observing learning behavior.

The paper identifies UNC-45A expression in proliferative cells of the mouse genital tract and microtubule-rich areas of the nervous system, suggesting its potential role in ovarian cancer and neurodegeneration.

This study identifies molecular determinants controlling Arpp19 phosphatase-inhibitory activity and reveals a feedback loop between two phosphorylation sites.

This study shows that zebrafish prc1l is essential for microtubule reorganization during cytokinesis and axis induction in early embryos.