Viral gastroenteritis research and epidemiology

The paper determines the structure of norovirus NS3 and proposes it functions as an RNA translocase.

This study uses cryogenic electron tomography to visualize the mechanism of membrane perforation during rhesus rotavirus entry, linking structural data with live-cell imaging.

This study identifies two distinct capsid conformations in human norovirus GII.3 virus-like particles, revealing conformational switching and alternative P domain interaction networks.

This study identifies cleavage sites and processing dynamics of astrovirus polyproteins, revealing conserved and divergent features between classical and non-classical strains.

This paper introduces a plasmid-based system using vaccinia virus capping enzymes to enhance calicivirus reverse genetics in mammalian cells, significantly increasing viral titres and polyprotein abundance.

This study identifies a single amino acid mutation in norovirus NS4 that rescues replication defects of a specialist virus, enabling it to spread more efficiently in vitro.

This study generates and characterizes monoclonal IgM and IgG antibodies against norovirus variants GII.4 and GII.17, revealing differences in binding mechanisms and affinity.

This study demonstrates that targeting G3BP1 for proteolysis using PROTACs reduces norovirus replication and prevents cell death.

This paper identifies critical molecular interactions of VP2 in HuNoV assembly through mutational analysis and computational modeling.

This paper investigates the role of the N-terminal domain of the capsid protein in calicivirus assembly and stability, showing its interaction with the viral genome and its impact on capsid structure and mechanical properties.

This study determines the structure of HAstV spikes bound to FcRn, identifies conserved epitopes, and suggests repurposing FcRn inhibitors for antiviral therapy.

This study identifies Trim47 as a host restriction factor that inhibits murine norovirus strain CR6 but not strain CW3, revealing strain-specific antiviral mechanisms.

This study compares NSP5/VP2-induced viroplasm-like structures across rotavirus species A-J, identifying species-specific differences and conserved mechanisms in VLS formation.

The paper compares GII.4 norovirus variants to determine if clustering and entry mechanisms are conserved, finding clustering enhances entry and is mediated by specific residues and lipid rafts.

This study identifies viral proteins involved in HAstV replication organelle formation by analyzing ER restructuring and DMV networks using microscopy techniques.

This study identifies that the LC protein from Feline calicivirus requires palmitoylation and disulfide bond-mediated oligomerization for efficient viral replication.

This study identifies structural constraints in rotavirus spike protein loops that regulate proteolytic activation necessary for infectivity.

The paper identifies an egress-enhancing mutation in murine norovirus that increases replication speed and viral titers in mice.

This paper develops a luciferase-based reporter system for murine norovirus to study replication and screen antiviral compounds.

This paper identifies allosteric escape mutants of murine norovirus that constitutively adopt the activated conformation, providing insights for vaccine design.

This study shows that lipid asymmetry, mediated by TMEM30a, is essential for murine norovirus entry and persistent infection.

This study shows a single amino acid change in a reovirus alters its infection outcome in mice with microbiota depletion, affecting tropism and sensitivity to microbiota-driven antiviral responses.

This study identifies conformational flexibility in GII proteases as a key factor affecting inhibitor potency, guiding the design of broad-spectrum norovirus protease inhibitors.

This study identifies three novel neutralizing antibody epitopes on the human astrovirus capsid spike using structural biology techniques and shows their role in blocking virus neutralization.

This study identifies NSP4 as a viroporin that induces intercellular calcium waves, contributing to rotavirus virulence through innate immune activation and disease severity.

This paper shows that 2'-fucosyllactose inhibits replication of a dominant human norovirus strain in intestinal enteroids from adult and pediatric donors.

This study shows that using a heat snap in RT-PCR increases rotavirus RNA quantification in environmental samples by 125-fold across different sample types and laboratories.

This study identifies FcRn and DPP4 as human astrovirus receptors and shows that targeting these factors with existing inhibitors prevents infection in human enteroid cultures.

This paper reports the cultivation of human noroviruses in human intestinal enteroids, revealing segment- and strain-specific differences in viral replication and highlighting the utility of genetically modified enteroids for broader strain cultivation.

This study identifies metabolic immaturity in newborns and maternal bile acids in breast milk as key factors increasing vulnerability to norovirus diarrhea.