Toxoplasma gondii Research Studies

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

This study uses human trophoblast stem cells to model placental resistance to Toxoplasma gondii and Listeria monocytogenes, showing that syncytiotrophoblasts are more resistant than cytotrophoblasts.

This study identifies eIF4E1 as a key regulator of Toxoplasma gondii latency by showing its role in translational control during encystation.

This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.

This study identifies TgTBC9 as an essential TBC-domain protein in Toxoplasma gondii that regulates Rab2 and ER-to-Golgi trafficking, offering therapeutic targets for apicomplexan parasites.

This study identifies and characterizes a Toxoplasma gondii O-glycosyltransferase, T.gondii-GalNAc-T3, revealing structural and functional differences from host homologues and identifying potential drug targets for parasitic diseases.

This study identifies TgCrk4 as a key regulator of the G2 phase in Toxoplasma gondii, controlling chromosome and centrosome cycles, and shows its evolutionary conservation in binary-dividing apicomplexans.

This study investigates the role of Toxoplasma gondii type II effector GRA15 in vivo, finding it has a limited impact on brain parasite burden and immune cell numbers at 3 weeks post-infection.

This study examines how iron depletion affects different Toxoplasma gondii strains, finding that acute strains are more sensitive than cystogenic strains.

This study investigates the dynamic properties of Toxoplasma gondii actin filaments, showing they undergo rapid disassembly and turnover due to unique biochemical features.

This study identifies a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein in Toxoplasma gondii that exhibits enzymatic activity but does not affect intracellular growth under hypoxia.

This paper identifies GRA47 and GRA72 as Toxoplasma gondii pore-forming proteins that regulate small molecule permeability of the parasitophorous vacuole, with mutations affecting their function and virulence.

This study shows that IFN-gamma induces CD115 and mTOR-dependent death of tissue-resident macrophages, enhancing host resistance to Toxoplasma gondii.

This study identifies apical annuli in Toxoplasma gondii as specialized sites for post-invasion secretion of dense granules, essential for parasite growth and host cell remodeling.

This study shows SPARK regulates PKA and PKG stability in Toxoplasma gondii, affecting its asexual cycle transitions.

The paper identifies a novel narnavirus, Apocryptovirus odysseus, potentially infecting Toxoplasma gondii, and suggests it may act as a pro-inflammatory factor in host cells.

This paper identifies TgUUT1 as a key pyrimidine salvage transporter in Toxoplasma gondii and demonstrates that 5F-uracil derivatives are potent antiparasitic agents with efficacy comparable to sulfadiazine.

The paper shows that pathogens can avoid immune degradation by using physical forces during entry, not just virulence factors.

The paper describes an outbreak of toxoplasmosis in captive primates during the COVID-19 pandemic, identifying Toxoplasma gondii as the causative agent through a collaborative, interdisciplinary investigation.

This study identifies p97/VCP as an IFN-gamma-dependent host factor that restricts Toxoplasma gondii by acidifying the parasitophorous vacuole in multiple human cell types.

This paper identifies extensive organellar DNA insertion into the nuclear genome of Toxoplasma gondii, revealing its role in genomic variation and potential functional impact.

This study identifies PPKL as a critical phosphatase for daughter parasite development in Toxoplasma gondii, showing its role in regulating cortical microtubules and the Crk1-dependent signaling pathway.

This paper identifies GRA83 as a Toxoplasma gondii effector that modulates host innate immunity, reducing parasite burden by enhancing inflammatory responses.

This study investigates how plant hormones affect the replication of Toxoplasma gondii tachyzoites in human cells, finding that abscisic acid promotes growth while gibberellic acid may inhibit it.

This study investigates the role of cortical microtubules in Toxoplasma gondii motility, showing that their destabilization reduces helical movement without affecting speed or invasion/egress.

This study identifies apicoplast transporters in Toxoplasma gondii using TurboID and genome engineering, showing AMT1 and AMT2 are critical for parasite growth and virulence.

This study shows that Toxoplasma gondii infection causes complement-dependent loss of inhibitory synapses on excitatory pyramidal neurons in the neocortex.

This study shows that IFN-γ stimulated murine and human neurons can clear Toxoplasma gondii parasites, challenging the dogma that neurons cannot mount anti-parasitic defenses.