Bone Metabolism and Diseases

Lysosomal cathepsin D regulates bone turnover through distinct mode of actions of the autophagy pathways in osteoblasts and osteoclasts

This study shows that CtsD regulates bone turnover through distinct autophagy mechanisms in osteoblasts and osteoclasts, suggesting it as a therapeutic target for bone mass maintenance.

The molecular and cellular interplay between the osteopetrosis-associated proteins SNX10, OSTM1, and CLC-7 during osteoclastogenesis

This study investigates the molecular interactions between SNX10, CLC-7, and OSTM1 in osteoclasts, showing they regulate lysosome distribution and fusion during osteoclastogenesis.

Lactobacillus acidophilus ameliorates inflammatory bone loss under post-menopausal osteoporotic conditions via preventing the pathogenic conversion of gut resident pTregs into Th17 cells

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

Harnessing the immune system to treat bone loss: The immunomodulatory and osteoprotective effects of the microalga Skeletonema costatum

This study investigates the osteoprotective effects of Skeletonema costatum extract by modulating immune pathways in zebrafish and medaka models, showing inhibition of osteoclast differentiation and bone loss.

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

This paper improves a murine bone marrow injury model to study intramembranous ossification and assess postnatal osteogenesis regulators.

Shear stress inhibits adipocyte differentiation via downregulating lncRNA MALAT1

This study shows shear stress inhibits adipocyte differentiation by downregulating lncRNA MALAT1 in mesenchymal stem cells, linking mechanical cues to lncRNA regulation in bone remodeling.

Homeostatic balance of Gut-resident Tregs (GTregs) plays a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions

This study shows that gut-resident Tregs (GTregs) regulate bone health in post-menopausal osteoporosis by modulating osteoblast and osteoclast activity, with probiotics and SCFAs enhancing their effectiveness.

The Role Of Fzd8 For Bone Development And Homeostasis In A Mouse Model Generated By CRISPR/Cas9 Genome Editing

This study generates an Fzd8-knockout mouse model using CRISPR/Cas9 to investigate its role in bone development and homeostasis, finding altered osteoclast and osteoblast activity and potential links to osteoporosis.

MiR-125b differentially impacts mineralization in dexamethasone and calcium-treated human mesenchymal stem cells

This study shows miR-125b differentially affects mineralization in hMSCs under dexamethasone or calcium treatment, with opposite effects on osteogenic markers and target gene modulation.

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

This study identifies miR-335-3p as a key regulator of osteoclast activity under psychological stress, showing its downregulation leads to FOS accumulation and osteoporosis.

Restoring oxidative phosphorylation enhances osteogenesis in mitochondrial DNA translation defective human bone marrow stromal cells

Osteogenic CpG oligodeoxynucleotide, iSN40, inhibits osteoclastogenesis in a TLR9-dependent manner

This study shows that iSN40, a CpG-ODN, inhibits osteoclast formation via TLR9-dependent mechanisms and may be a therapeutic for osteoporosis.

Rejuvenating aged osteoprogenitors for bone repair

This study identifies age-related impairments in bone healing and presents a rejuvenation strategy combining Wnt-mediated osteoprogenitor expansion and intermittent fasting to restore youthful bone repair in aged mice.

Stage-Specific Modulation of Multinucleation, Fusion and Resorption by the Long Non-coding RNA DLEU1 and miR-16 in Human Primary Osteoclasts

This study shows that DLEU1 and miR-16 regulate osteoclast fusion and resorption through distinct mechanisms, suggesting potential therapeutic targets for bone diseases.

Mechanism of NPC1L1 mediated 27-hydroxycholesterol metabolisms in the occurrence and development of osteoporosis

This study shows NPC1L1 inhibits osteogenesis and promotes osteoporosis by regulating cholesterol metabolism through the C/EBP/Cyp27a1/27-OHC axis.

Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

This study finds that inflammation in bone of T2D and obesity patients is linked to reduced Wnt signaling and lower bone strength.

CD11B+CD36+ cells are bone anabolic macrophages that limit age-associated bone loss

This study identifies CD11B+CD36+ macrophages as bone anabolic cells that limit age-related cortical bone loss in mice and humans.

Osterix Facilitates Osteocytic Communication by Targeting Connexin43

This study shows Osterix maintains osteocytic dendrites and intercellular communication by regulating Connexin43, impacting bone homeostasis and disease.

Mechanosensing by Piezo1 regulates osteoclast differentiation via PP2A-Akt axis in periodontitis

This study shows that Piezo1 on preosteoclasts reduces osteoclast formation and bone resorption in periodontitis via the PP2A-Akt pathway.

Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

This study shows that inhibiting Cx3cr1+iOCs enhances CGRP+TrkA+ sensory signaling and accelerates callus remodeling in osteoporotic fractures.

Phase diagrams of bone remodeling using a 3D stochastic cellular automaton

This paper introduces a 3D stochastic cellular automaton model to simulate bone remodeling dynamics and derives a phase diagram showing how parameter changes affect the process.

Loss of ninein interferes with osteoclast formation and causes premature ossification

This study shows that ninein deficiency impairs osteoclast formation and bone resorption, leading to premature ossification and altered skeletal development.

Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow

This study shows that targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by modulating signaling pathways and stem cell fate.

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface associated La protein

This study identifies an oxidized form of La protein at the osteoclast surface, driven by ROS signaling, which promotes multinucleation and bone resorption.

A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone

This study creates a harmonized atlas of murine bone-associated cells using single-cell RNA sequencing to clarify cell type designations and identify osteoblast progenitors.

Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

The paper identifies KLF16 as an inhibitory regulator of osteogenic differentiation through transcriptomic analysis of human iPSC-derived cells and in vivo validation.

Loss of coactosin-like F-actin binding protein 1 (Cotl1) decreases platelet-mediated osteoclastogenesis and causes osteopetrosis phenotypes in mouse

This study shows that loss of Cotl1 in mice reduces platelet-mediated osteoclastogenesis, leading to osteopetrosis, and identifies a genetic association between COTL1 variants and bone density in humans.

Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females

This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.

The calcium channel Orai1 is required for osteoblast development: studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

This study shows that Orai1 is essential for osteoblast development by using chimeric mice with conditional deletion of Orai1 in osteoprogenitor cells, revealing impaired bone formation and mineralization.