Bone Metabolism and Diseases

Immune-Derived THBS1-CD47 Axis Induces Cellular Senescence and Suppresses Osteogenesis in Diabetic Periosteum

This study identifies the THBS1-CD47 axis as a driver of periosteal dysfunction in T2DM, showing it induces cellular senescence and suppresses osteogenesis, with therapeutic potential in diabetic bone repair.

T-regulatory cell protection of progenitor cells from CD4+ T-cell-mediated cytotoxicity is essential for endogenous mouse digit-tip regeneration.

The paper shows CD4+ T cells inhibit digit-tip regeneration by attacking progenitor cells, which can be counteracted by T regulatory cells or RANKL.

Dual-lineage human 3D bone niche model reveals osteoclast-driven osteomimicry in prostate cancer

This paper develops a 3D bone niche model to study prostate cancer-bone interactions, finding that osteoclasts drive osteomimicry in cancer cells.

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

This study deletes Scarb1 in osteoblast progenitors and myeloid cells and finds no effect on bone mass.

Targeting the Alk4 pathway protects against age-related bone loss.

This study shows inhibiting the Alk4 pathway in aging mice prevents age-related bone loss and sarcopenia by reducing Activin signaling.

Identification of novel bone-resorption markers by osteoclasts in vitro and in vivo

This study identifies 22 novel bone-resorption markers produced by osteoclasts in vitro and validates 14 in human biofluids, with two fragments elevated in bone metastasis urine.

ILC3 inhibits Osteoclastogenesis and ameliorates Inflammatory Bone Loss in Post-menopausal Osteoporosis

This study shows that ILC3 inhibits osteoclastogenesis and reduces inflammatory bone loss in post-menopausal osteoporosis by modulating ILC3 subsets and function.

A Mathematical Model to Predict Instantaneous Bone Formation Rate from Temporal Data of Cellular Biomarkers

The paper develops a mathematical model to predict bone formation rate from Col1a1 gene expression data and compares it with literature-reported average BFR.

Elevated surface La promotes hyperfusion and contributes to impaired resorption in osteopetrosis.

This study identifies elevated surface La as a cause of hyperfusion and impaired resorption in osteopetrosis and shows that inhibiting La can restore osteoclast function.

Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective

This study investigates dexamethasone-induced bone toxicity in developing bones using single-cell transcriptomics in mice, revealing reduced osteoblast and chondrocyte populations and disrupted B cell development.

Tartrate-resistant acid phosphatase (TRAP/ACP5) sex-specifically regulates bone maintenance in old mice, but the anabolic effects of mechanical loading is regulated in a sex-independent way

This study shows TRAP regulates sex-specific bone maintenance and mechanical loading responses in old mice, with TRAP-deficiency impairing bone formation in both sexes.

ARHGAP10 is a novel microtubule-associated protein that regulates the resorption activity of osteoclasts

This study identifies ARHGAP10 as a microtubule-associated protein critical for osteoclast function, showing it regulates actin ring dynamics and resorption activity through its interaction with microtubules and RHO-GTPases.

Moesin controls cell-cell fusion and osteoclast function

This study identifies moesin's role in osteoclast fusion and function, showing its impact on bone resorption and disease therapy.

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells

This study investigates how mitochondrial reactive oxygen species (mtROS) affect bone mesenchymal cells, showing impaired mitochondrial function and NAD+ levels, and suggests combined therapies targeting mtROS, senescence, and NAD+ may delay age-related osteoporosis.

CRISPR activation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

This study shows that increasing autophagy in osteoblast lineage cells via CRISPR activation of Tfeb improves bone mass and strength in mice.

Serum Amyloid P Secreted by Bone Marrow Adipocytes Drives Skeletal Amyloidosis

This study shows that senescent bone marrow adipocytes secrete SAP/PTX2, which promotes skeletal amyloidosis and bone loss in aging mice.

Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors

This study shows that chronic alcohol consumption increases the differentiation of hematopoietic stem and progenitor cells into osteoclast precursors, contributing to reduced bone density.

Interleukin-3 as a Potential Bone Anabolic Agent in treating Postmenopausal Osteoporosis

IL-3 treatment preserves trabecular bone architecture and enhances bone mineral density in ovariectomized mice, showing dual anti-osteoclastic and pro-osteoblastic effects in postmenopausal osteoporosis.

Estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts

This study shows estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts, reducing bone resorption through suppression of SIRT3 activity.

Osteoblast-derived Nerve Growth Factor is Required for Skeletal Adaptation to Mechanical Load and the Osteoanabolic Effect of Gambogic Amide in Mice

This study shows that osteoblast-derived NGF is essential for bone adaptation to mechanical load and that gambogic amide requires endogenous NGF for its osteoanabolic effects in mice.

Sexual dimorphism of MASLD-driven bone loss

This study investigates sex differences in bone loss associated with MASLD using DIAMOND mice, identifying potential liver-secreted factors involved in bone resorption.

Proliferation of Early and Mature Osteoblasts Is Required for Bone Fracture Healing in Mice

This study shows that proliferation of early and mature osteoblasts is essential for bone fracture healing in mice, as blocking their proliferation leads to fibrous nonunion and reduced callus formation.

The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.

A Novel Optimized Silver Nitrate Staining Method for Visualizing the Osteocyte Lacuno-Canalicular System

This paper introduces an optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system, showing improved staining consistency and LCS detection across species.

Osteocyte Differentiation Requires Glycolysis, But Mature Osteocytes Display Metabolic Flexibility

This study shows glycolysis is essential for osteocyte differentiation but mature osteocytes switch to metabolic flexibility, including increased fatty acid oxidation in response to mechanical stress.

Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I

This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic agent.

Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis

This paper shows cathepsin K inhibitors enhance osteoclast-osteoblast communication and promote osteogenesis, suggesting their unique role in balancing bone resorption and formation.

G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

This study shows GPR35 agonists reduce osteoclast activity in human cells by inhibiting bone resorption pathways, with effects comparable to existing osteoporosis drugs.

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts

The paper uses high-content imaging to identify anti-resorptive GPCRs in human osteoclasts, finding four receptors that reduce osteoclast activity.