Immune cells in cancer

This study shows that CD206+ macrophages support an anti-tumor network involving cDC1, NK cells, and CD8 T cells, and their depletion impairs tumor control in mice and correlates with poor survival in humans.

The paper shows that blocking monocytes alone is insufficient to reduce LMAMs, as KCs can replenish them through proliferation or infiltration, and their reprogramming contributes to immunosuppression.

This study uses real-time imaging in zebrafish to show that macrophage protrusive motility, regulated by Rac2, influences melanoma invasion.

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

The paper shows that tumor-associated macrophages overexpress thymidine phosphorylase, leading to resistance to TAS-102 chemotherapy in digestive cancers.

This study identifies shared and distinct mechanisms of macrophage programming by IL4 and glucocorticoids, revealing GRIP1's role in integrating their effects on transcription and function.

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

This study shows that blocking CSF-1R in tumor-associated macrophages alters their metabolism, enhancing sensitivity to 5-fluorouracil in colorectal cancer.

This study identifies M-CSF and IL-34 as drivers of M-MDSC differentiation and T cell suppression in glioblastoma, with NOS involvement and microenvironmental niches contributing to M-MDSC heterogeneity.

This study shows that sepiapterin reprograms M2-type tumor-associated macrophages in HER2+ breast tumors to M1-type by modulating arginine metabolism, enhancing immunotherapy response.

This study shows metastasized breast cancer cells eliminate CD169+ macrophages from lymph nodes, impairing anti-cancer immunity.

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

This study identifies distinct tumor-TAM interactions in IDH-stratified gliomas using single-cell and spatial transcriptomics, revealing potential therapeutic targets in IDH-WT glioblastoma.

This paper reviews preclinical studies on PI3K-gamma inhibition to reverse myeloid-driven immune suppression in solid tumours, finding that combination therapies show greater antitumor effects than monotherapy.

This study identifies a prostate cancer-induced endothelial-to-osteoblast transition that creates an immunosuppressive bone tumor microenvironment, reducing the effectiveness of immune checkpoint therapy in bone metastatic castrate-resistant prostate cancer.

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

This study identifies macrophages as key drivers of BCG therapy's anti-tumoral effect through direct TNF-mediated cancer cell killing, independent of adaptive immunity.

This study identifies IL-1R signaling as a driver of enteric glia-macrophage interactions in colorectal cancer, promoting tumor progression through IL-6 secretion.

This study shows targeting a STING agonist to perivascular macrophages in ADT-treated prostate tumors delays castration resistance prostate cancer onset.

This study shows hypoxia alters macrophage gene expression through increased mRNA decay, leading to tumorigenic phenotypes.

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

This study uses topic modeling to analyze nanoparticle targeting of macrophages in tumors over 20 years, identifying 6 topics and trends in nanoparticle usage and therapeutic strategies.

This paper uses longitudinal scRNA-seq to study immune changes in lung metastasis, identifying inflammatory programs and signaling networks associated with metastatic progression.

This study identifies distinct functions and fates of murine classical monocytes derived from GMP and MDP, showing differential contributions to tissue macrophage populations.

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

The study identifies seven chemokine-expressing interstitial macrophage subsets in the lung and shows their role in controlling inflammatory cell influx and tertiary lymphoid formation.

This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.

This study identifies how cancer genetics shape the tumor microenvironment in hepatocellular carcinoma, revealing myeloid cell-specific vulnerabilities that can be targeted with GM-CSF inhibition.