Invertebrate Immune Response Mechanisms

This study tracks the progression of OrV infection in C. elegans, identifying four infection stages and gene expression changes, revealing virus-specific and general immune responses.

The paper identifies lysosomal TIR-1/SARM1 as a sensor for oxidative stress induced by pathogenic bacteria, activating intestinal immunity in C. elegans.

This study manually annotates and refines gene models of the Toll pathway in 19 anopheline and 2 culicine mosquito genomes, revealing evolutionary constraints and radiation patterns.

The paper investigates bed bug immune responses to three bacterial challenges using transcriptomics and phylogenetic analysis, finding differential gene expression patterns and lineage-specific gene duplications.

This study shows high-sugar diets increase susceptibility to certain bacterial infections in Drosophila by impairing antimicrobial peptide production and promoting pathogen growth.

This study shows that elevated temperatures enhance antiviral defenses in arthropods by activating HSF1 to upregulate antimicrobial peptides targeting viral envelopes.

This study shows that late-stage Plasmodium parasites in mosquitoes are susceptible to melanization, with distinct immune regulation for different stages.

The paper detects known and novel viruses in black soldier flies and identifies antiviral gene expression differences.

The paper characterizes immune cells in Pacific oysters using single-cell RNA sequencing and other methods, identifying seven functionally distinct cell types and three hematopoietic lineages.

This study identifies DRH-1 as a C. elegans RIG-I-like receptor that uses 2CARD domains to activate anti-viral immunity in intestinal cells, showing parallels with mammalian RIG-I signaling.

The paper reports genotype-specific expression of uncle fester in botryllid ascidians, showing it correlates with rejection response speed and severity, suggesting a role in allorecognition education.

This paper shows parasitoid wasps suppress Drosophila JAK-STAT pathway activity to evade immune defenses.

This study shows that a latent Pseudomonas aeruginosa infection in Drosophila melanogaster is silenced by an innate immune response, specifically melanization, and provides protection against secondary infections.

This study investigates the prevalence and causes of wounding in wild Drosophila melanogaster, finding that 31% of individuals were wounded, with females more frequently injured on the ventral abdomen.

This study shows that viral infection disrupts intestinal homeostasis in Drosophila by activating Sting-dependent NF-kB signaling, leading to ISC proliferation and reduced lifespan.

This study shows acid-treated Staphylococcus aureus induces melanization in silkworm hemolymph, with S. aureus proteins playing a role in innate immune activation.

This study shows that activating innate immunity in Aedes aegypti reduces mitochondrial complex I activity, proline oxidation, and flight activity, indicating a trade-off between immunity and dispersal.

This study identifies cryptic virulence and protective roles of individual CeMbio bacteria in C. elegans, highlighting the importance of HLH-30/TFEB in host defense.

This study compares the transcriptional responses of mosquitoes to different pathogens and finds that they distinguish between fungi and bacteria but not Gram types.

This study shows that JAK/STAT signaling in muscles causes insulin resistance, redirecting nutrients to immune cells and improving survival during parasitoid infection in Drosophila.

This study identifies Turandot stress proteins that protect Drosophila tissues from antimicrobial peptide-induced damage by binding phosphatidylserine and inhibiting AMP pore formation.

This study identifies hemocyte heterogeneity and pleiotropic roles in ticks using multi-omics approaches, revealing their impact on immunity, metabolism, and arthropod fitness.

The paper investigates how mitochondrial variation affects the costs of immune stimulation in Drosophila, finding mitotype-specific effects on lifespan, fecundity, and locomotor activity.

This study uses proteomics to compare C. elegans responses to two protective Pseudomonas symbionts, identifying distinct host pathways involved in pathogen resistance and tolerance.

This study quantifies the trade-off between immune investment and host fitness by manipulating cactus knock-down in flour beetles, revealing dose-dependent benefits and costs to infection resistance and other fitness traits.

This paper develops a live flow cytometry method to analyze Galleria mellonella hemocytes and measure phagocytosis, showing 80% of hemocytes are phagocytic and demonstrating Candida albicans subverts phagocytosis.

This study shows that phospholipase A2 activity is essential for immune defense in European and Asian honeybees against Paenibacillus larvae, with PLA2A and PLA2B specifically inhibiting immune responses.