Discover, rate, and discuss biology preprints.

This study shows that higher tumor-stroma proportion (TSP) in ovarian cancer is linked to worse patient outcomes, including shorter progression-free and overall survival, and increased chemoresistance.

The paper assesses apple diseases and insect pests in Southern Ethiopia and finds low grower awareness and poor management practices.

This paper introduces a photonic chip-based microscopy method for super-resolution imaging of FFPE tissue sections, demonstrating improved contrast and compatibility with histological workflows.

This study compares straight and curved extension dialysis catheters in dogs with AKI, finding straight catheters offer lower resistance during CRRT.

This study demonstrates that combining nitrite and red light treatment reduces device thrombosis in extracorporeal circulation, improving survival and preserving platelet numbers.

This study identifies micro-circulating hyperdynamic blood flow as a universal pathogenic mechanism in early sepsis, leading to oxygen exchange disorder and hypoxia through the Bernoulli effect.

This study examines DNA methylation in genes associated with schistosomiasis-associated bladder cancer in children and bladder cancer tissues, finding methylation in tumor suppressor genes linked to the disease.

This study develops a mouse model of repetitive sulfur dioxide exposure that mimics post-deployment respiratory syndrome features, identifying oxidative stress as a mediator of pulmonary vascular disease.

This study shows that Aedes aegypti can transmit Jamestown Canyon Virus (JCV) and that Wolbachia only moderately blocks JCV replication, suggesting distinct mechanisms for blocking negative-sense vs. positive-sense viruses.

This paper introduces TransNuc, a deep learning model for detecting and classifying cell nuclei in histology images, showing improved performance across various cancer types.

EZH2 inhibition causes repeat misexpression and B cell death by mimicking viral infection in splenic B cells.

The paper investigates the association between low circulating choline and Alzheimer's disease progression, finding it linked to neuropathological features and metabolome dysfunction.

This study compares a non-toxic Glyoxal fixative with formaldehyde in veterinary pathology, finding better molecular preservation and comparable histological results.

The paper examines how anxiety levels affect risk and loss aversion in decision-making tasks and their relation to pandemic-related behaviors.

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

This study shows African-lineage Zika virus can be vertically transmitted to rhesus macaque fetuses with a low dose, similar to Asian-lineage viruses.

The paper develops molecular tools to detect and identify Pseudomonas syringae strains causing zucchini vein clearing by designing primers and qPCR tests for specific genetic clusters.

This study shows SMARCA4 drives hemin-induced chromatin changes in macrophages, switching their phagocytic target from leukocytes to erythrocytes, contributing to atherosclerosis.

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

This study develops phenotyping and genotyping workflows to detect fungicide resistance in Pyrenophora teres pathogens, identifying prevalent resistance alleles in South and Western Australia.