The paper examines how higher order interactions affect community stability in aquatic protist communities by analyzing persistence and interaction strength across different community compositions.

bioRxiv · May 4, 2023Ecology

Synaptotagmin-9 and Tomosyn-1 molecular complex regulates Stx1A SNAREs to inhibit insulin secretion from pancreatic beta-cells

M. M. Rahman, A. Pathak, K. L. Schueler, H. A. Alsharif, A. N. Michl, J. Alexander, J.-a. Kim, E. R. Chapman, S. Bhatnagar

This study shows that synaptotagmin-9 inhibits insulin secretion by forming a complex with Tomosyn-1 and Stx1A, reducing SNARE complex formation in pancreatic beta-cells.

bioRxiv · Oct 20, 2022 · PreprintCell Biology

Identification and characterization of four bacteriome- and mycobiome-derived subtypes in tumour and adjacent mucosa tissue of colorectal cancer patients

M. Salvucci, L. Poynter, R. Minerzami, S. Carberry, R. O'Byrne, J. Alexander, D. Lambrechts, K. Veselkov, J. Kinross, J. H. M. Prehn

This paper identifies four microbial subtypes in colorectal cancer tumours and adjacent mucosa, linking them to clinical and molecular features and demonstrating prognostic value.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

A. Zelceski, P. Francica, L. Lingg, M. Mutlu, C. Stok, M. Liptay, J. Alexander, J. S. Baxter, R. Brough, A. Gulati, S. Haider, M. Raghunandan, F. Song, S. Sridhar, J. V. Forment, , C. J. Lord

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

bioRxiv · Aug 24, 2022Cancer Biology

Using machine learning to understand microgeographic determinants of the Zika vector, Aedes aegypti

J. Alexander, A. B. B. Wilke, A. Mantero, C. Vasquez, W. Petrie, N. Kumar, J. C. Beier

This study uses machine learning to analyze mosquito population dynamics in Miami-Dade County, finding neighborhood-specific factors influencing Zika vector distribution.

bioRxiv · Mar 3, 2022Ecology

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity

I. Manuelyan, A. M. Schmoker, B. L. Yount, P. Eisenhauer, J. I. Keller, C. Gold, D. Terino, C. M. Ziegler, J. Alexander, H. E. Driscoll, E. Hutchinson, D. Bhella, C. D. Syme, D. G. Widman, M. T. Heise, , J. W. Botten

This study maps host-driven post-translational modifications on the Zika virus proteome, identifies key phosphosites, and shows how an FDA-approved kinase inhibitor blocks viral growth.

bioRxiv · Nov 24, 2021 · PreprintMicrobiology

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

E. Song, C. M. Bartley, R. D. Chow, T. Ngo, R. Jiang, C. R. Zamecnik, R. Dandekar, R. Loudermilk, Y. Dai, F. Liu, I. Hawes, B. D. Alvarenga, T. Huynh, L. McAlpine, N.-T. Rahman, , S. F. Farhadian

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

bioRxiv · Sep 11, 2020Immunology

Towards establishing no observed adverse effect levels (NOAEL) for different sources 1 of dietary phosphorus in feline adult diets: results from a 7 month feeding study

J. C. Coltherd, J. Alexander, C. Pink, J. Rawlings, R. Haydock, L. J. Carvell-Miller, R. F. Butterwick, D. W. Logan, P. Watson, A. M. Bakke, J. Elliott, L. Molina, V. Biourge

This study evaluates the safety of high dietary phosphorus in cats over 7 months, finding no adverse effects at up to 5g/1000kcal from sodium tripolyphosphate.

bioRxiv · Sep 1, 2020Pharmacology & Toxicology

Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis

U. Jungwirth, A. van Weverwijk, L. Jenkins, J. Alexander, D. Vicente, Q. Gao, S. Haider, M. Iravani, C. M. Isacke

The paper identifies a specific cancer-associated fibroblast subset that supports tumour growth and metastasis by expressing Endo180, and shows that targeting this subset can limit tumour progression.

bioRxiv · May 17, 2020Cancer Biology