A. Amon

A noncanonical GTPase signaling mechanism controls exit from mitosis in budding yeast

This study reveals a noncanonical GTPase signaling mechanism in budding yeast where Tem1 localization, not its nucleotide state, controls MEN activation by increasing effective concentration for Cdc15 interaction.

The environmental stress response regulates ribosome content in cell cycle-arrested S. cerevisiae

This study shows that cell cycle arrest in S. cerevisiae triggers ribosome downregulation via the Environmental Stress Response (ESR), linking cell cycle progression to biomass accumulation.

Decreasing Mitochondrial RNA Polymerase Activity Reverses Biased Inheritance of Hypersuppressive mtDNA

Cell size is a determinant of stem cell potential during aging

The paper shows that stem cell enlargement during aging reduces their function, and preventing this enlargement improves function.

Cross-compartment signal propagation in the Mitotic Exit Network

The paper shows how the MEN signal is transmitted from the cytoplasm to the nucleolus through kinase-mediated phosphorylation in budding yeast.

Aneuploid cells activate NF-κB to promote their immune clearance by NK cells

The paper shows aneuploid cells activate NF-κB to promote NK cell-mediated immune clearance, with NF-κB inactivation blocking this process in vitro.

The environmental stress response causes ribosome loss in aneuploid yeast cells.

This study clarifies that aneuploid yeast cells exhibit the environmental stress response (ESR) rather than the CAGE signature, leading to ribosome loss and reduced cellular density.

Aneuploidy and deregulated DNA damage response define haploinsufficiency in breast tissues of BRCA2 mutation carriers

The paper identifies sub-chromosomal copy number variations and DNA damage in BRCA2 mutation carriers' breast tissues, indicating haploinsufficiency and early carcinogenic changes.

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution

This paper uses Monte Carlo modeling to show that aneuploid cell frequency peaks after bone marrow transplantation due to reduced purifying selection from population expansion and radiation-induced niche damage.