T. P. Miettinen

The paper shows that steady-state growth in bacterial cultures occurs only after high dilution from stationary phase and is characterized by stable mass distribution.

The paper quantifies sinking velocities of unicellular algae to show their dependence on cell size, light, and nutrients, revealing mechanisms linking cell composition to vertical movement.

The paper shows that nucleotide imbalances during S phase disrupt DNA replication and cell proliferation, requiring replication stress signaling for survival.

The paper develops a single-cell method to monitor dry mass and density during mitosis, revealing exocytosis-driven changes in cellular composition.

The paper shows that stem cell enlargement during aging reduces their function, and preventing this enlargement improves function.

This study shows that intracellular density in fission yeast changes during the cell cycle due to volume growth modulation, with density decreasing in G2, increasing in mitosis, and dropping at cell birth.

The paper measures mass growth of polyploid mouse lymphocytes to show that cell cycle, not cell size, primarily determines growth efficiency.

The paper quantifies mitochondrial ATP synthesis rates during mitosis and finds a 50% decrease in early mitosis linked to CDK1 activity.

This study uses thermal proteome profiling to show palbociclib induces proteasome stabilization and senescence in breast cancer cells via ECM29 loss, with ECM29 mRNA levels linked to relapse-free survival.