Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy
J. Yang, J. Zhu, Y. Chen, Y. Du, Y. Tan, L. Wu, J. Sun, M. Zhai, L. Wei, N. Li, K. Huang, Q. Hou, Z. Tong, A. Bechthold, Z. Sun, C. Zuo
This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.
bioRxiv · Nov 1, 2021Cancer Biology