A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis
L. Fan, Q. Pan, W. Yang, S. C. Koo, C. Tian, L. Li, M. Lu, A. Brown, B. Ju, J. Easton, S. Ranganathan, S. Shin, A. Bondoc, J. J. Yang, J. Yu, L. Zhu
This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.
bioRxiv · Oct 22, 2021Cancer Biology