S. Ranganathan

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

This study demonstrates that peptide amphiphile nanostructures enhance cancer imaging and therapy by hitchhiking on endogenous biomolecules to target tumors effectively.

Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon

This study maps 1225 protein-protein interactions in E. coli's 1-carbon metabolism pathway, revealing conserved interfaces that mediate transient interactions and enhance metabolic flux.

A Drug-Free Pathogen Capture and Neutralizing Nasal Spray to Prevent Emerging Respiratory Infections

This paper introduces a drug-free nasal spray that captures and neutralizes respiratory pathogens, showing high efficacy in mice against influenza.

Enzymatic metabolon improves kinetic efficiency of reaction-limited enzyme pathways

This study shows that metabolons enhance metabolic flux for reaction-limited enzymes but not diffusion-limited ones, suggesting an evolutionary strategy for compensating inefficiency through clustering.

Identification of novel PGRP3 protein -protein interactions using yeast two hybrid system

This study identifies and validates two novel PGRP3-interacting proteins, MBNL3 and RBP5, using yeast two-hybrid screening and co-immunoprecipitation.

Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates

This study shows phosphorylation sites prevent liquid-solid transitions in FUS condensates by reducing β-sheet propensity and stabilizing liquid-like states.

TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma

The paper investigates TRPA1 expression in oral cancer cell lines and normal cells, finding TRPA1 absent in cancer cells, suggesting its potential as a prognostic indicator.

The physics of liquid-to-solid transitions in multi-domain protein condensates

This study uses simulations to show how multi-domain RNA-binding proteins transition from disordered to ordered, solid-like structures, with implications for disease-related changes.

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

This study investigates the interaction between the Myc and Mlx networks in liver regeneration and tumorigenesis, finding that the Mlx network plays a critical role in maintaining homeostasis and suppressing tumor formation.

Role of non-specific interactions in the phase-separation and maturation of macromolecules

This paper investigates how non-specific interactions influence phase separation and maturation of polymers, showing an optimal range of interaction strengths for forming functional biomolecular complexes.

Effect of RNA on morphology and dynamics of membraneless organelles.

This study shows RNA promotes phase separation of protein clusters by acting as super-scaffolds, enabling liquid-like dynamics at low protein concentrations.

Genomic diversity and antimicrobial resistance of Haemophilus colonising the airways of young children with cystic fibrosis

This study examines Haemophilus colonization and antimicrobial resistance in children with cystic fibrosis, finding high prevalence and diverse AMR mechanisms.

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

This study shows that patient-derived NFE2L2 mutants drive aggressive hepatoblastomas in mice by accelerating tumor growth and promoting necrosis and cyst formation.

Liquid-liquid microphase separation leads to formation of membraneless organelles

The paper shows that multi-valent proteins form micro-phase separated droplets through arrested macro-phase separation, which is dynamic and functional, unlike the static macro-phase separation predicted by traditional models.