A. Brown

The paper creates a graph database to integrate SARS-CoV-2 phylogenetic trees, metadata, and surveillance data for phylodynamic analysis.

The paper identifies extensive non-coding sequence divergence in A. fumigatus compared to related species, highlighting its potential role in virulence.

This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.

This study investigates transcriptional heterogeneity in Aspergillus fumigatus strains responding to caspofungin, identifying a core response and variable response linked to secondary metabolite biosynthesis and iron homeostasis.

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

This study shows peritumoral myofibroblasts suppress iCCA growth but promote metastasis through Vcam1-dependent mechanisms.

The paper tracks neurofilament movement in axons, showing that length regulation via severing and annealing affects transport, with phosphorylation modulating these processes.

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

The paper uses FISH with chromosome-arm specific oligo painting probes to analyze chromosome structure differences in banana species and cultivars, revealing translocations and aiding in understanding their genomic evolution.

The paper describes methods for purifying SARS-CoV-2 spike protein, its receptor binding domain, and CR3022 mAb, and validates their use in serological assays.

The paper examines how mercury contamination interacts with immunity and infection in Neotropical bats, finding that higher mercury levels are linked to lower infection odds in some species but not others.

This study shows that reducing Pex11β decreases peroxisomes and reverses palmitate's negative impact on beta-cell function.

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

The paper reports cryo-EM structures of the BBSome in inactive and active states, revealing how ARL6 binding activates the complex and how disease mutations disrupt its function.

The paper examines hemoplasma infection prevalence and genetic diversity in Neotropical bats, finding high host specificity and phylogenetic constraints on bacterial sharing.

Castanet, a targeted metagenomic sequencing method, improves pathogen detection in clinical samples by combining sensitivity with cost-effectiveness and broad organism coverage.

This study improves the reliability of PhD career outcome classification by revising a taxonomy and guidance document based on inter-rater reliability testing.

This study identifies normalization parameters that significantly affect differential abundance analysis in metabolomics of intracellular parasites, highlighting the impact of host contamination.