A. D'Souza

XPA tumor variants lead to defects in NER that sensitize cells to cisplatin

This study identifies XPA tumor variants that impair NER, increasing cisplatin sensitivity, and provides mechanistic insights for variant effect prediction.

Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair

The paper investigates two interaction surfaces between XPA and RPA in the preincision complex of nucleotide excision repair, showing their distinct roles in complex assembly and NER activity.

Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

The paper analyzes Antibiotic_NAT family enzymes to understand resistance diversification, finding environmental variants confer broad-spectrum resistance and likely ancestral relationships to clinical genes.

Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

This paper develops a breath-based cancer detection system using engineered D-limonene production in tumors, achieving high sensitivity and specificity in mice and predicting human tumor detection limits.

Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells

This paper shows that microvesicles transfer mitochondria to brain endothelial cells and neurons, increasing ATP levels under ischemic conditions, while exosomes do not affect mitochondrial function.

Arboreal aperitifs: Space use and activity of a major songbird nest predator in a tropical Thailand forest

This study tracks the movement and activity of green cat snakes in a Thai forest, linking their behavior to avian nest predation patterns.