G. Wright

The Caenorhabditis elegans bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion

The paper shows that certain bacteria reduce microsporidia infection in C. elegans by altering host metabolism and producing inhibitory compounds.

A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling in Pseudomonas aeruginosa

The paper shows that a single extracellular loop of FoxA controls ligand specificity, uptake, and signaling in Pseudomonas aeruginosa by affecting different siderophores.

Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family

The paper analyzes Antibiotic_NAT family enzymes to understand resistance diversification, finding environmental variants confer broad-spectrum resistance and likely ancestral relationships to clinical genes.

Pollen sterols are associated with phylogenetics and environment but not with pollinators

This study quantifies pollen phytosterols across 122 plant species and finds phylogenetic clustering and environmental adaptation but no link to pollinator guilds.

A novel human fetal liver-derived model reveals that MLL-AF4 drives a distinct fetal gene expression program in infant ALL

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

Single-molecule fluorescence-based approach reveals novel mechanistic insights into small heat shock protein chaperone function

This study uses single-molecule fluorescence to reveal a two-step mechanism by which human Bc (HSPB5) interacts with misfolded proteins to prevent aggregation.

Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells

This study shows that vinculin loss in murine skin disrupts adherens junctions, leading to loss of bulge stem cell quiescence through impaired force generation and YAP1 retention.

Genome location dictates the transcriptional response to PolC-inhibition in Clostridium difficile

This study shows that genome location influences the transcriptional response to PolC-inhibition in C. difficile, with origin-proximal genes being more upregulated.

Mesophotic Coral Ecosystems Inside and Outside a Caribbean Marine Protected Area

This study quantifies mesophotic coral ecosystems (MCEs) in and around a Caribbean marine protected area, finding similar ecological communities but highlighting differences in fish species and the absence of large-bodied fish.