M. Ferguson

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

This paper uses the Epivolve phage display method to generate monoclonal antibodies targeting a subdominant epitope on Treponema pallidum BamA, showing opsonic activity in macrophage assays.

Relish/NF-kB acts in intestinal stem cells to promote epithelial repair in Drosophila

This study shows that NF-kB in intestinal stem cells is crucial for epithelial repair in Drosophila, as its loss impairs tissue regeneration and increases mortality.

Immune Regulation of Intestinal Stem Cell Proliferation and Differentiation in Drosophila.

This study shows that immune signaling in Drosophila intestinal stem cells is critical for maintaining epithelial homeostasis, with impaired immunity leading to reduced stem cell numbers and defective differentiation.

Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

A panel of single nucleotide polymorphism (SNP) markers identifies potential duplicates in cassava (Manihot esculenta Crantz) varieties from Cote dIvoire

The paper identifies potential duplicate cassava varieties using a SNP panel, finding 11 unknown duplicates and confirming known ones, with low genetic differentiation among sub-populations.

Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine.

This study shows that Lactobacillus brevis affects stem cell division symmetry and tumorigenesis in Drosophila intestine by altering integrin expression and distribution.

Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

This study identifies large structural variants as a significant source of homologous repair deficiency in high-grade serous ovarian carcinoma, beyond known SNVs and indels at BRCA1/2.

Multispectral Imaging Differentiates Unique Macrophage Profiles in Patients with Distinct Chronic Liver Diseases

This study uses multispectral imaging to analyze macrophage profiles in liver biopsies from patients with chronic liver diseases, revealing distinct macrophage phenotypes associated with different fibrosis stages and disease types.

Complex symbiont-pathogen interactions inhibit intestinal repair

This study shows that Vibrio cholerae inhibits intestinal epithelial repair in Drosophila by interacting with symbiotic bacteria, highlighting the role of the type six secretion system in pathogenesis.

The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila.

This study shows that the IMD pathway in Drosophila affects metabolic homeostasis, with mutations leading to metabolic dysregulation and altered infection responses.

Constitutive Immune Activity Promotes Tumorigenesis in Drosophila Intestinal Progenitor Cells.

This study shows that continuous immune activity in Drosophila intestinal progenitor cells disrupts homeostasis and promotes tumor formation.