Author

P. Caswell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bolado-Carrancio· 1 shared A. Charles-Orszag· 1 shared A. Ewing· 1 shared A. Hoyle· 1 shared A. PICKARD· 1 shared A. Reid· 1 shared A. von Kriegsheim· 1 shared C. Semple· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bolado-Carrancio

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

D. Newman, L. Young, T. Waring, L. Brown, K. Wolanska, E. MacDonald, A. Charles-Orszag, P. Caswell, T. Sakuma, T. Yamamoto, L. M. Machesky, M. Morgan, T. N. Zech

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

bioRxiv · May 17, 2021 · PreprintCell Biology

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

J. CHANG, A. PICKARD, J. A. Herrera, S. O'Keefe, M. Hartshorn, R. GARVA, A. Hoyle, L. Dingle, C. Zeltz, J. Wong, A. Reid, R. V. Venkateswaran, Y. Lu, P. Caswell, S. High, , K. E. KADLER

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

bioRxiv · Mar 25, 2021Cell Biology

Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration

J. Hetmanski, M. Jones, F. Chunara, J.-M. Schwartz, P. Caswell

This study uses three mathematical models to analyze rear retraction dynamics in 3D cell migration, revealing new insights and predicting CDK1 inhibition as a potential strategy to block cell movement.

bioRxiv · Aug 3, 2020Cell Biology

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

A. von Kriegsheim, A. Bolado-Carrancio, M. Muir, A. Ewing, K. Macleod, W. Gallagher, L. Nguyen, N. O. Carragher, C. Semple, V. Brunton, P. Caswell

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

bioRxiv · Sep 12, 2019Cancer Biology