Author

J.-S. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 3 Cancer Biology· 2 Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 5 Approach:experimental assay· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Organism:yeast· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2

Frequent Co-Authors

S. N. Cullati· 4 shared K. L. Gould· 3 shared A. Fiser· 2 shared C. Guetta-Terrier· 2 shared D. Karambizi· 2 shared J. E. Fajardo· 2 shared K. Gould· 2 shared L. Ren· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

S. N. Cullati

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10 papers

Recent·Most cited

Substrate displacement of CK1 C-termini regulates kinase specificity

S. N. Cullati, K. Akizuki, J.-S. Chen, K. N. Gould

The paper shows that autophosphorylated C-termini of CK1 kinases act as inhibitory pseudosubstrates, and their displacement by substrates regulates kinase specificity.

bioRxiv · Jun 30, 2023Biochemistry

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

S. N. Cullati, E. Zhang, Y. Shan, R. X. Guillen, J.-S. Chen, J. Navarrete-Perea, Z. C. Elmore, L. Ren, S. P. Gygi, K. L. Gould

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

bioRxiv · Apr 27, 2023 · PreprintCell Biology

Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins

A. H. Willet, L. Ren, J.-S. Chen, K. Gould

This study identifies Ank1 as a binding partner of Myo1 in fission yeast, showing it inhibits Myo1 membrane binding through interactions with the lever arm and TH1 domain, and suggests Ank1 orthologs regulate myosin-1 in endocytosis.

bioRxiv · Apr 26, 2023Cell Biology

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

R. Bhattacharjee, A. Hall, M. C. Mangione, M. G. Igarashi, R. H. Roberts-Galbraith, J.-S. Chen, D. Vavylonis, K. Gould

This study shows that phosphorylation by multiple kinases inhibits Cdc15 phase separation and prevents cytokinetic ring assembly in fission yeast.

bioRxiv · Aug 26, 2022Cell Biology

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

C. Guetta-Terrier, D. Karambizi, B. Akosman, J.-S. Chen, S. Kamle, J. E. Fajardo, A. Fiser, R. Singh, S. A. Toms, C. G. Lee, J. A. Elias, N. Tapinos

This study shows Chi3l1 modulates glioma stem cell states by altering transcription factor activity and cell state transitions, and demonstrates anti-Chi3l1 antibody treatment inhibits glioblastoma growth.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

J. P. Zepecki, D. Karambizi, J. E. Fajardo, K. M. Snyder, C. Guetta-Terrier, O. Y. Tang, J.-S. Chen, A. Sarkar, A. Fiser, S. A. Toms, N. Tapinos

The paper shows that miRNA-mediated loss of m6A increases nascent translation in glioblastoma stem cells during differentiation.

bioRxiv · Aug 28, 2020Cancer Biology

Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro

Y. Chen, W.-H. Yang, L.-M. Huang, Y.-C. Wang, C.-S. Yang, Y.-L. Liu, M.-H. Hou, C.-L. Tsai, Y.-Z. Chou, B.-Y. Huang, C.-F. Hung, Y.-L. Hung, J.-S. Chen, Y.-P. Chiang, D.-Y. Cho, , M.-C. Hung

This study identifies tafenoquine as an inhibitor of SARS-CoV-2 main protease, showing it reduces protease activity and inhibits viral infection in vitro.

bioRxiv · Aug 14, 2020 · PreprintBiochemistry

Autophosphorylation of the CK1 kinase domain regulates enzyme activity and function

S. N. Cullati, J.-S. Chen, K. L. Gould

This study identifies a conserved autophosphorylation mechanism in CK1 kinases that inhibits activity, with implications for disease and regulation.

bioRxiv · Jun 5, 2019Biochemistry

Active Transport of Membrane Components by Self-Organization of the Min Proteins

Y.-L. Shih, L.-T. Huang, Y.-M. Tu, B.-F. Lee, Y.-C. Bau, C. Y. Hong, H.-l. Lee, Y.-P. Shih, M.-F. Hsu, J.-S. Chen, Z.-X. Lu, L. Chao

The paper shows that Min protein waves create steric pressure to direct membrane component distribution, following a physical principle similar to peristaltic pumping.

bioRxiv · Sep 14, 2018Biophysics

Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization

C. M. Jones, J.-S. Chen, A. E. Johnson, Z. C. Elmore, S. N. Cullati, J. R. Beckley, K. L. Gould

This study shows that Dma1's transient removal from SPBs during anaphase B, driven by auto-ubiquitination, is essential for silencing the Dma1-dependent mitotic checkpoint in fission yeast.

bioRxiv · May 15, 2018Cell Biology