Author

A. G. Murzin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Assay:electronic health records· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

M. Goedert· 3 shared B. Falcon· 2 shared R. A. Crowther· 2 shared S. H. W. Scheres· 2 shared W. Zhang· 2 shared A. Kotecha· 1 shared B. Ghetti· 1 shared D. Kimanius· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

M. Goedert

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Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivJul 24, 2023

Disease-specific tau filaments assemble via polymorphic intermediates

S. Lövestam, D. Li, J. L. Wagstaff…·S. H. W. Scheres

This study uses cryo-EM to analyze intermediate structures in tau filament assembly, revealing shared and condition-dependent intermediates in Alzheimer's and CTE pathogenesis.

DOI 10.1038/s41586-023-06788-w

electronic health recordsexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivNov 13, 2018

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

W. Zhang, B. Falcon, A. G. Murzin…·S. H. W. Scheres

This study characterizes heparin-induced tau filaments using cryo-EM and immuno-EM, revealing structural diversity and differences from Alzheimer’s and Pick’s disease filaments.

DOI 10.7554/elife.43584

humancryo-EM

𝕏 PostBluesky

BiophysicsbioRxivApr 16, 2018

Structures of filaments from Pick’s disease reveal a novel tau protein fold

B. Falcon, W. Zhang, A. G. Murzin…·M. Goedert

This paper determines the structure of tau filaments from Pick’s disease using cryo-EM, revealing a novel tau protein fold distinct from Alzheimer's disease filaments.

DOI 10.1038/s41586-018-0454-y

humancryo-EM

𝕏 PostBluesky