Author

M. Goedert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:cryo-EM· 2 Assay:electronic health records· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

A. G. Murzin· 3 shared B. Falcon· 2 shared R. A. Crowther· 2 shared S. H. W. Scheres· 2 shared W. Zhang· 2 shared A. Kotecha· 1 shared B. Ghetti· 1 shared D. Kimanius· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

A. G. Murzin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Disease-specific tau filaments assemble via polymorphic intermediates

S. Lövestam, D. Li, J. L. Wagstaff, A. Kotecha, D. Kimanius, S. H. McLaughlin, A. G. Murzin, S. M. V. Freund, M. Goedert, S. H. W. Scheres

This study uses cryo-EM to analyze intermediate structures in tau filament assembly, revealing shared and condition-dependent intermediates in Alzheimer's and CTE pathogenesis.

bioRxiv · Jul 24, 2023Biophysics

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

W. Zhang, B. Falcon, A. G. Murzin, J. Fan, R. A. Crowther, M. Goedert, S. H. W. Scheres

This study characterizes heparin-induced tau filaments using cryo-EM and immuno-EM, revealing structural diversity and differences from Alzheimer’s and Pick’s disease filaments.

bioRxiv · Nov 13, 2018Biophysics

Structures of filaments from Pick’s disease reveal a novel tau protein fold

B. Falcon, W. Zhang, A. G. Murzin, G. Murshudov, H. J. Garringer, R. Vidal, R. A. Crowther, B. Ghetti, S. Scheres, M. Goedert

This paper determines the structure of tau filaments from Pick’s disease using cryo-EM, revealing a novel tau protein fold distinct from Alzheimer's disease filaments.

bioRxiv · Apr 16, 2018Biophysics