A. Geerlof

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

This paper investigates how RBM5's RNA-binding domains recognize specific RNA motifs to regulate alternative splicing, revealing structural and cooperative mechanisms.

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1

The paper shows hnRNP proteins modulate MALT1 pre-mRNA structure to regulate alternative splicing of exon7 by competing for RNA stem-loop binding.

Defining the RBPome of T helper cells to study higher order post-transcriptional gene regulation

The paper identifies the core RNA-binding protein (RBP)ome in human and mouse T helper cells, revealing new regulators of post-transcriptional gene regulation, including Celf1 as a Roquin-1-dependent coregulator of Icos.

Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2

The paper determines the structure of the Drosophila LS2 protein's RRM domains and shows they interact with G quadruplex RNA motifs to regulate alternative splicing.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

Molecular recognition and dynamics of linear poly-ubiquitins: integrating coarse-grain simulations and experiments

This paper combines coarse-grain simulations and experiments to study the conformational dynamics of linear poly-ubiquitin chains and their interaction with NEMO.