A. Hegde

Partial alopecia area retains bulge hair follicle progenitor cells in Indian androgenetic alopecia patients

The paper identifies that progenitor cells persist in partially bald areas of Indian AGA patients but are absent in completely bald areas, suggesting a timeframe for therapeutic intervention.

Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis

This study identifies Angptl2 as a driver of fibrotic vasculopathy in a mouse model of SSc and shows that inhibiting its effects can reduce fibrogenesis.

Extracellular caspase-1 regulates hair follicle stem cell migration during wound-healing

This study identifies extracellular Caspase-1 as a chemoattractant that drives hair follicle stem cell migration during wound healing.

The initiation of the wound healing program is regulated by the convergence of mechanical and epigenetic cues

This study identifies how mechanical tension in the epidermis triggers DNA methylation changes via DNMT3a, leading to gene expression shifts that initiate wound healing.