Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis
D. Saha, S. Thannimangalath, N. Pincha, R. Kiran, A. Hegde, S. Kataria, B. Dam, A. Hiwale, V. Ravula, L. M. Rahulan, N. Nigam, N. Singh, V. Agarwal, P. K. Vemula, C. Jamora
This study identifies Angptl2 as a driver of fibrotic vasculopathy in a mouse model of SSc and shows that inhibiting its effects can reduce fibrogenesis.
bioRxiv · Oct 16, 2023Pathology