J. Lan

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

Targeted induction of gut-microbial metabolism acutely affects feeding patterns and clock gene expression in the host

This study shows that increasing gut microbial metabolism in mice affects host clock gene expression and reduces food intake beyond microbial calorie contribution.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle

This study shows that a gnotobiotic microbiota affects metabolic processes differently depending on the circadian cycle, influencing energy balance and substrate utilization.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

Susceptibilities of human ACE2 genetic variants in coronavirus infection

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM

This paper introduces a reduced graphene oxide membrane as a supporting film for cryo-EM, improving resolution and particle absorption for sub-100 kDa biomolecules.

SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

Machine Learning-based Biomarkers Identification and Validation from Toxicogenomics - Bridging to Regulatory Relevant Phenotypic Endpoints

The paper identifies and validates biomarkers using machine learning to predict in vivo phenotypic toxicity endpoints from in vitro toxicogenomic data.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

The paper determines cryo-EM structures of bat and pangolin coronavirus spikes, showing PCoV_GX spike binds human ACE2 like SARS-CoV-2, while RaTG13 does not, and identifies key residues and glycans involved in RBD function.

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

A functional chromogen gene C from wild rice is involved in a different anthocyanin biosynthesis pathway in indica and japonica

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Potent human neutralizing antibodies elicited by SARS-CoV-2 infection

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

This study shows that inhibiting both mitochondrial translation and dynamics in C. elegans synergistically extends lifespan through HLH-30-dependent lysosome biogenesis and autophagy.

Palmitoylation is critically required for cancer intrinsic PD-1 expression and functions

This study identifies PD-1 palmitoylation, its regulatory enzyme, and develops a peptide inhibitor to target PD-1 expression for cancer immunotherapy.