Author

N. Ma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Bioengineering· 2 Cancer Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

N. Vaidehi· 4 shared E. Mukhaleva· 2 shared W. J. C. Van Der Velden· 2 shared A. Kulasinghe· 1 shared A. Manglik· 1 shared A. Marson· 1 shared A. Pratapa· 1 shared A. S. RODIN· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersBiophysics

N. Vaidehi

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in beta-2 Adrenergic Receptor

E. Mukhaleva, T. Yang, F. R. Sadler, S. Sivaramakrishnan, N. Ma, N. Vaidehi

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.

bioRxiv · Nov 28, 2023Biophysics

Bayesian network models identify co-operative GPCR:G protein interactions that contribute to G protein coupling

E. Mukhaleva, N. Ma, W. J. C. Van Der Velden, G. Gogoshin, S. Branciamore, S. Bhattacharya, A. S. RODIN, N. Vaidehi

This study uses Bayesian network modeling to identify cooperative GPCR:G protein interactions and their allosteric effects, revealing subnetworks that contribute to G protein coupling selectivity.

bioRxiv · Oct 9, 2023Biophysics

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

Q. Feng, K. Cheng, L. Zhang, X. Gao, J. Liang, G. Liu, N. Ma, C. Xu, M. Tang, L. Chen, X. Wang, X. Ma, J. Zou, Q. Shi, P. Du, , X. Zhao

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

bioRxiv · Aug 24, 2023 · PreprintBioengineering

Single-cell Spatial Metabolic and Immune Phenotyping of Head and Neck Cancer Tissues Identifies Tissue Signatures of Response and Resistance to Immunotherapy

N. Jhaveri, B. Ben Cheikh, N. Nikulina, N. Ma, D. Klymyshyn, J. DeRosa, R. Mihani, A. Pratapa, Y. Kassim, S. Bommakanti, O. Shang, Y. He, Y. Zheng, J. Monkman, C. Cooper, , O. Braubach

This study uses single-cell spatial analysis to identify immune and metabolic tumor microenvironment signatures associated with response and resistance to immunotherapy in head and neck cancer.

bioRxiv · May 30, 2023Cancer Biology

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

J. Lee, M. E. Robinson, R. Sun, K. Kume, N. Ma, K. N. Cosgun, L. N. Chan, E. Leveille, H. Geng, V. S. Vykunta, B. R. Shy, A. Marson, S. G. Katz, J. Chen, E. Paietta, , M. Mueschen

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Structural basis of odorant recognition by a human odorant receptor

C. B. Billesboelle, C. A. de March, W. J. C. van der Velden, N. Ma, J. Tewari, C. Linas del Torrent, L. Li, B. Faust, N. Vaidehi, H. Matsunami, A. Manglik

The paper determines the structure of a human odorant receptor bound to propionate, revealing how odorant recognition and activation occur through specific molecular interactions.

bioRxiv · Dec 20, 2022 · PreprintBiochemistry

Optogenetic operated probiotics to regulate host metabolism by mimicking enteroendocrine

X. Zhang, N. Ma, W. Ling, G. Pang, T. Sun, J. Liu, H. Pan, M. Cui, C. Han, C. Yang, J. Chang, X. Huang, H. Wang

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

bioRxiv · Nov 30, 2021 · PreprintBioengineering

Microfluidic system-based time-course tracking of physical proximity between cells and its effect on gene expression for elucidating live single cancer-immune cell interactions

B. C. T. Flores, S. Chawla, N. Ma, C. Sanada, P. K. Kujur, L. T. D. Chinen, K. Hukari, M. Lynch, N. Ramalingam, D. Sengupta, S. S. Jeffrey

This study tracks physical proximity between NK and TNBC cells over time using a microfluidic system and links it to gene expression changes, revealing transcriptional memory in immune-cancer interactions.

bioRxiv · Nov 13, 2021 · PreprintCancer Biology

A novel deep-sea bacterial threonine dehydratase drives cysteine desulfuration and hydrogen sulfide production

N. Ma, Y. Sun, W. Zhang, C. Sun

The paper identifies a deep-sea bacterial threonine dehydratase that catalyzes cysteine desulfuration to produce hydrogen sulfide, revealing structural and functional mechanisms.

bioRxiv · Dec 23, 2020 · PreprintMicrobiology

Activation microswitches in GPCRs function as rheostats in cell membrane

N. Ma, S. Lee, N. Vaidehi

This study uses molecular dynamics simulations to show that GPCR activation in cell membranes involves microswitches and is regulated by PIP2 and calcium ions, differing from detergent environments.

Biochemistry · Oct 27, 2020Peer-reviewedBiophysics