Author

A. L. Kaplan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

B. K. Shoichet· 3 shared F. Liu· 2 shared J. J. Irwin· 2 shared Y. S. Moroz· 2 shared A. Basbaum· 1 shared B. L. Roth· 1 shared C.-G. Wu· 1 shared C.-L. Tu· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

B. K. Shoichet

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3 papers

Recent·Most cited

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

F. Liu, C.-G. Wu, C.-L. Tu, I. Glenn, J. Meyerowitz, A. L. Kaplan, J. Lyu, Z. Cheng, O. O. Tarkhanova, Y. S. Moroz, J. J. Irwin, W. Chang, B. K. Shoichet, G. Skiniotis

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

bioRxiv · Dec 27, 2023 · PreprintBiophysics

Structure-based discovery of CFTR potentiators and inhibitors

F. Liu, A. L. Kaplan, J. Levring, J. Einsiedel, S. Tiedt, K. Distler, N. Omattage, I. S. Kondratov, Y. S. Moroz, H. L. Pietz, J. J. Irwin, P. Gmeiner, B. K. Shoichet, J. Chen

The paper identifies novel CFTR modulators using molecular docking, electrophysiology, cryo-EM, and medicinal chemistry, discovering potentiators and inhibitors with mid-nanomolar activity.

bioRxiv · Sep 9, 2023Biophysics

Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor

A. L. Kaplan, R. T. Strachan, J. M. Braz, V. Craik, S. Slocum, T. Mangano, V. Amabo, H. R. O'Donnell, P. Lak, A. Basbaum, B. L. Roth, B. K. Shoichet

The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.

bioRxiv · Dec 6, 2021 · PreprintBiophysics